DC Field | Value | Language |
---|---|---|
dc.contributor.author | Liang, Chengyu | ko |
dc.contributor.author | Oh, Byung-Ha | ko |
dc.contributor.author | Jung, Jae U. | ko |
dc.date.accessioned | 2015-04-07T02:39:52Z | - |
dc.date.available | 2015-04-07T02:39:52Z | - |
dc.date.created | 2015-01-06 | - |
dc.date.created | 2015-01-06 | - |
dc.date.issued | 2015-01 | - |
dc.identifier.citation | NATURE REVIEWS MICROBIOLOGY, v.13, no.1, pp.7 - 12 | - |
dc.identifier.issn | 1740-1526 | - |
dc.identifier.uri | http://hdl.handle.net/10203/195108 | - |
dc.description.abstract | Cellular apoptosis is of major importance in the struggle between virus and host. Although many viruses use various strategies to control the cell death machinery by encoding anti-apoptotic virulence factors, it is now becoming clear that, in addition to their role in inhibiting apoptosis, these factors function in multiple immune and metabolic pathways to promote fitness and pathogenesis. In this Progress article, we discuss novel functions of viral anti-apoptotic factors in the regulation of autophagy, in the nuclear factor-kappa B (NF-kappa B) pathway and in interferon signalling, with a focus on persistent and oncogenic gamnnaherpesviruses. If viral anti-apoptotic proteins are to be properly exploited as targets for antiviral drugs, their diverse and complex roles should be considered. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | NF-KAPPA-B | - |
dc.subject | SARCOMA-ASSOCIATED HERPESVIRUS | - |
dc.subject | TRANSCRIPTION FACTORS | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | ONCOGENIC VIRUSES | - |
dc.subject | KSHV VFLIP | - |
dc.subject | IKK-GAMMA | - |
dc.subject | PROTEIN | - |
dc.subject | ACTIVATION | - |
dc.subject | AUTOPHAGY | - |
dc.title | Novel functions of viral anti-apoptotic factors | - |
dc.type | Article | - |
dc.identifier.wosid | 000347135900007 | - |
dc.identifier.scopusid | 2-s2.0-84926637700 | - |
dc.type.rims | ART | - |
dc.citation.volume | 13 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 7 | - |
dc.citation.endingpage | 12 | - |
dc.citation.publicationname | NATURE REVIEWS MICROBIOLOGY | - |
dc.identifier.doi | 10.1038/nrmicro3369 | - |
dc.contributor.localauthor | Oh, Byung-Ha | - |
dc.contributor.nonIdAuthor | Liang, Chengyu | - |
dc.contributor.nonIdAuthor | Jung, Jae U. | - |
dc.type.journalArticle | Review | - |
dc.subject.keywordPlus | NF-KAPPA-B | - |
dc.subject.keywordPlus | SARCOMA-ASSOCIATED HERPESVIRUS | - |
dc.subject.keywordPlus | TRANSCRIPTION FACTORS | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | ONCOGENIC VIRUSES | - |
dc.subject.keywordPlus | KSHV VFLIP | - |
dc.subject.keywordPlus | IKK-GAMMA | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | AUTOPHAGY | - |
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