Melanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia

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dc.contributor.authorBerglund, Eric D.ko
dc.contributor.authorLiu, Tieminko
dc.contributor.authorKong, Xingxingko
dc.contributor.authorSohn, Jong Wooko
dc.contributor.authorVong, Linhko
dc.contributor.authorDeng, Zhuoko
dc.contributor.authorLee, Charlotte E.ko
dc.contributor.authorLee, Syannko
dc.contributor.authorWilliams, Kevin W.ko
dc.contributor.authorOlson, David P.ko
dc.contributor.authorScherer, Philipp E.ko
dc.contributor.authorLowell, Bradford B.ko
dc.contributor.authorElmquist, Joel K.ko
dc.date.accessioned2015-03-27T08:06:30Z-
dc.date.available2015-03-27T08:06:30Z-
dc.date.created2014-07-29-
dc.date.created2014-07-29-
dc.date.issued2014-07-
dc.identifier.citationNATURE NEUROSCIENCE, v.17, no.7, pp.911 - 913-
dc.identifier.issn1097-6256-
dc.identifier.urihttp://hdl.handle.net/10203/194547-
dc.description.abstractWhether melanocortin 4 receptors (MC4Rs) in extra-hypothalamic neurons, including cholinergic autonomic pre-ganglionic neurons, are required to control energy and glucose homeostasis is unclear. We found that MC4Rs in sympathetic, but not parasympathetic, pre-ganglionic neurons were required to regulate energy expenditure and body weight, including thermogenic responses to diet and cold exposure and 'beiging' of white adipose tissue. Deletion of Mc4r genes in both sympathetic and parasympathetic cholinergic neurons impaired glucose homeostasis.-
dc.languageEnglish-
dc.publisherNATURE PUBLISHING GROUP-
dc.subjectBROWN ADIPOSE-TISSUE-
dc.subjectADAPTIVE THERMOGENESIS-
dc.subjectGLUCOSE-HOMEOSTASIS-
dc.subjectOBESITY-
dc.subjectACTIVATION-
dc.subjectCIRCUITRY-
dc.subjectRESPONSES-
dc.subjectHUMANS-
dc.subjectMICE-
dc.titleMelanocortin 4 receptors in autonomic neurons regulate thermogenesis and glycemia-
dc.typeArticle-
dc.identifier.wosid000338097200007-
dc.identifier.scopusid2-s2.0-84903381007-
dc.type.rimsART-
dc.citation.volume17-
dc.citation.issue7-
dc.citation.beginningpage911-
dc.citation.endingpage913-
dc.citation.publicationnameNATURE NEUROSCIENCE-
dc.identifier.doi10.1038/nn.3737-
dc.contributor.localauthorSohn, Jong Woo-
dc.contributor.nonIdAuthorBerglund, Eric D.-
dc.contributor.nonIdAuthorLiu, Tiemin-
dc.contributor.nonIdAuthorKong, Xingxing-
dc.contributor.nonIdAuthorVong, Linh-
dc.contributor.nonIdAuthorDeng, Zhuo-
dc.contributor.nonIdAuthorLee, Charlotte E.-
dc.contributor.nonIdAuthorLee, Syann-
dc.contributor.nonIdAuthorWilliams, Kevin W.-
dc.contributor.nonIdAuthorOlson, David P.-
dc.contributor.nonIdAuthorScherer, Philipp E.-
dc.contributor.nonIdAuthorLowell, Bradford B.-
dc.contributor.nonIdAuthorElmquist, Joel K.-
dc.type.journalArticleArticle-
dc.subject.keywordPlusBROWN ADIPOSE-TISSUE-
dc.subject.keywordPlusADAPTIVE THERMOGENESIS-
dc.subject.keywordPlusGLUCOSE-HOMEOSTASIS-
dc.subject.keywordPlusOBESITY-
dc.subject.keywordPlusACTIVATION-
dc.subject.keywordPlusCIRCUITRY-
dc.subject.keywordPlusRESPONSES-
dc.subject.keywordPlusHUMANS-
dc.subject.keywordPlusMICE-
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