DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shi, Mude | ko |
dc.contributor.author | Cho, Hyelim | ko |
dc.contributor.author | Inn, Kyung-Soo | ko |
dc.contributor.author | Yang, Aerin | ko |
dc.contributor.author | Zhao, Zhen | ko |
dc.contributor.author | Liang, Qiming | ko |
dc.contributor.author | Versteeg, Gijs A. | ko |
dc.contributor.author | Amini-Bavil-Olyaee, Samad | ko |
dc.contributor.author | Wong, Lai-Yee | ko |
dc.contributor.author | Zlokovic, Berislav V. | ko |
dc.contributor.author | Park, Hee-Sung | ko |
dc.contributor.author | Garcia-Sastre, Adolfo | ko |
dc.contributor.author | Jung, Jae U. | ko |
dc.date.accessioned | 2015-03-27T08:03:58Z | - |
dc.date.available | 2015-03-27T08:03:58Z | - |
dc.date.created | 2014-11-11 | - |
dc.date.created | 2014-11-11 | - |
dc.date.issued | 2014-09 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.5 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/194532 | - |
dc.description.abstract | The TRIpartite Motif (TRIM) family of RING-domain-containing proteins participate in a variety of cellular functions. The beta-transducin repeat-containing protein (beta-TrCP), a component of the Skp-Cullin-F-box-containing (SCF) E3 ubiquitin ligase complex, recognizes the NF-kappa B inhibitor I kappa B alpha and precursor p100 for proteasomal degradation and processing, respectively. beta-TrCP thus plays a critical role in both canonical and non-canonical NF-kappa B activation. Here we report that TRIM9 is a negative regulator of NF-kappa B activation. Interaction between the phosphorylated degron motif of TRIM9 and the WD40 repeat region of beta-TrCP prevented beta-TrCP from binding its substrates, stabilizing I kappa B alpha and p100 and thereby blocking NF-kappa B activation. Consequently, expression or depletion of the TRIM9 gene significantly affected NF-kappa B-induced inflammatory cytokine production. This study not only elucidates a mechanism for TRIM9-mediated regulation of the beta-TrCP SCF complex activity but also identifies TRIM9 as a brain-specific negative regulator of the NF-kappa B pro-inflammatory signalling pathway. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | TRIM FAMILY PROTEINS | - |
dc.subject | E3 UBIQUITIN LIGASE | - |
dc.subject | BETA-TRCP | - |
dc.subject | SIGNALING PATHWAYS | - |
dc.subject | IKK-ALPHA | - |
dc.subject | DOWN-REGULATION | - |
dc.subject | TNF-ALPHA | - |
dc.subject | DEGRADATION | - |
dc.subject | ACTIVATION | - |
dc.subject | DISEASE | - |
dc.title | Negative regulation of NF-kappa B activity by brain-specific TRIpartite Motif protein 9 | - |
dc.type | Article | - |
dc.identifier.wosid | 000342929200001 | - |
dc.identifier.scopusid | 2-s2.0-84920285386 | - |
dc.type.rims | ART | - |
dc.citation.volume | 5 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms5820 | - |
dc.contributor.localauthor | Park, Hee-Sung | - |
dc.contributor.nonIdAuthor | Shi, Mude | - |
dc.contributor.nonIdAuthor | Cho, Hyelim | - |
dc.contributor.nonIdAuthor | Inn, Kyung-Soo | - |
dc.contributor.nonIdAuthor | Zhao, Zhen | - |
dc.contributor.nonIdAuthor | Liang, Qiming | - |
dc.contributor.nonIdAuthor | Versteeg, Gijs A. | - |
dc.contributor.nonIdAuthor | Amini-Bavil-Olyaee, Samad | - |
dc.contributor.nonIdAuthor | Wong, Lai-Yee | - |
dc.contributor.nonIdAuthor | Zlokovic, Berislav V. | - |
dc.contributor.nonIdAuthor | Garcia-Sastre, Adolfo | - |
dc.contributor.nonIdAuthor | Jung, Jae U. | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | TRIM FAMILY PROTEINS | - |
dc.subject.keywordPlus | E3 UBIQUITIN LIGASE | - |
dc.subject.keywordPlus | BETA-TRCP | - |
dc.subject.keywordPlus | SIGNALING PATHWAYS | - |
dc.subject.keywordPlus | IKK-ALPHA | - |
dc.subject.keywordPlus | DOWN-REGULATION | - |
dc.subject.keywordPlus | TNF-ALPHA | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | DISEASE | - |
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