Kaposi's Sarcoma-Associated Herpesvirus K7 Modulates Rubicon-Mediated Inhibition of Autophagosome Maturation

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Autophagy is an important innate safeguard mechanism for protecting an organism against invasion by pathogens. We have previously discovered that Kaposi's sarcoma-associated herpesvirus (KSHV) evades this host defense through tight suppression of autophagy by targeting multiple steps of autophagy signal transduction. Here, we report that KSHV K7 protein interacts with Rubicon autophagy protein and inhibits the autophagosome maturation step by blocking Vps34 enzymatic activity, further highlighting how KSHV deregulates autophagy-mediated host immunity for its life cycle.
Publisher
AMER SOC MICROBIOLOGY
Issue Date
2013-11
Language
English
Article Type
Article
Keywords

REGULATORY FACTOR 7; PROTEIN; PHOSPHORYLATION; COMPLEX; TARGETS; ATG14L; UVRAG; ORF45; LC3

Citation

JOURNAL OF VIROLOGY, v.87, no.22, pp.12499 - 12503

ISSN
0022-538X
DOI
10.1128/JVI.01898-13
URI
http://hdl.handle.net/10203/192464
Appears in Collection
BS-Journal Papers(저널논문)
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