Antibiofouling amphiphilic polymer-coated superparamagnetic iron oxide nanoparticles: synthesis, characterization, and use in cancer imaging in vivo

Cited 74 time in webofscience Cited 0 time in scopus
  • Hit : 133
  • Download : 0
Superparamagnetic iron oxide nanoparticles (SPIONs) are widely used as T2-contrast agents for magnetic resonance imaging (MRI). Herein we develop various antibiofouling amphiphilic polymer-coated SPIONs using a one-step nanoemulsion method. This methodology yielded ultrasmall polymer-coated SPIONs, of average diameter less than 30 nm, which were stable under physiological conditions. In vitro cell cytotoxicity tests revealed that no SPION showed toxicity even at relatively high concentrations. In vivo MRI with Lewis lung carcinoma (LLC) tumor-bearing mice resulted in an approximately 30% T2 signal drop in tumor tissues, indicating that the SPIONs reached such tissues via passive targeting. In summary, the ultrasmall, stable, amphiphilic polymer-coated SPIONs can be used as MRI contrast agents for cancer imaging.
Publisher
ROYAL SOC CHEMISTRY
Issue Date
2009-06
Language
English
Article Type
Article
Keywords

RESONANCE CONTRAST AGENTS; MAGNETIC-RESONANCE; QUANTUM DOTS; MACROMOLECULAR THERAPEUTICS; DRUG-DELIVERY; NANOCRYSTALS; THERAPY; CELLS

Citation

JOURNAL OF MATERIALS CHEMISTRY, v.19, no.35, pp.6412 - 6417

ISSN
0959-9428
DOI
10.1039/b902445j
URI
http://hdl.handle.net/10203/192411
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 74 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0