DC Field | Value | Language |
---|---|---|
dc.contributor.author | Namgung, Ran | ko |
dc.contributor.author | Singha, Kaushik | ko |
dc.contributor.author | Yu, Mi Kyung | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.contributor.author | Kim, Yong Sook | ko |
dc.contributor.author | Ahn, Youngkeun | ko |
dc.contributor.author | Park, In-Kyu | ko |
dc.contributor.author | Kim, Won Jong | ko |
dc.date.accessioned | 2014-12-09T01:29:22Z | - |
dc.date.available | 2014-12-09T01:29:22Z | - |
dc.date.created | 2014-08-29 | - |
dc.date.created | 2014-08-29 | - |
dc.date.issued | 2010-05 | - |
dc.identifier.citation | BIOMATERIALS, v.31, no.14, pp.4204 - 4213 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | http://hdl.handle.net/10203/192404 | - |
dc.description.abstract | The work demonstrated the development of thermally cross-linked superparamagnetic nanomaterial which possessed polyethylene glycol moiety and covalently linked branched polyethylenimine (BPEI), and exhibited highly efficient magnetofection even under serum conditioned media. The study showed its high anti-biofouling, cell viability and serum stability and thus revealed a potential magnetic nanoparticle-mediated targeted gene delivery system. This superparamagnetic particle mediated rapid and efficient transfection in primary vascular endothelial cells (HUVEC) successfully inhibits expression of PAI-1 which is responsible for various vascular dysfunctions such as vascular inflammation and atherosclerosis and thereby provides a potential strategy to transfect highly sensitive HUVEC. The sequential steps for the enhanced magnetofection had been studied by monitoring cellular uptake with the aid of confocal microscopy. | - |
dc.language | English | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | BIODEGRADABLE POLYMERIC NANOPARTICLES | - |
dc.subject | IN-VIVO | - |
dc.subject | THERAPY PROGRESS | - |
dc.subject | MAGNETIC FORCE | - |
dc.subject | DNA DELIVERY | - |
dc.subject | ATHEROSCLEROSIS | - |
dc.subject | MAGNETOFECTION | - |
dc.subject | TRANSDUCTION | - |
dc.subject | ULTRASOUND | - |
dc.subject | PROSPECTS | - |
dc.title | Hybrid superparamagnetic iron oxide nanoparticle-branched polyethylenimine magnetoplexes for gene transfection of vascular endothelial cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000276541300050 | - |
dc.type.rims | ART | - |
dc.citation.volume | 31 | - |
dc.citation.issue | 14 | - |
dc.citation.beginningpage | 4204 | - |
dc.citation.endingpage | 4213 | - |
dc.citation.publicationname | BIOMATERIALS | - |
dc.identifier.doi | 10.1016/j.biomaterials.2010.01.123 | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Namgung, Ran | - |
dc.contributor.nonIdAuthor | Singha, Kaushik | - |
dc.contributor.nonIdAuthor | Yu, Mi Kyung | - |
dc.contributor.nonIdAuthor | Kim, Yong Sook | - |
dc.contributor.nonIdAuthor | Ahn, Youngkeun | - |
dc.contributor.nonIdAuthor | Park, In-Kyu | - |
dc.contributor.nonIdAuthor | Kim, Won Jong | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Magnetofection | - |
dc.subject.keywordAuthor | Superparamagnetic iron oxide | - |
dc.subject.keywordAuthor | Polyethylenimine | - |
dc.subject.keywordAuthor | Gene delivery | - |
dc.subject.keywordAuthor | Atherosclerosis | - |
dc.subject.keywordPlus | BIODEGRADABLE POLYMERIC NANOPARTICLES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | THERAPY PROGRESS | - |
dc.subject.keywordPlus | MAGNETIC FORCE | - |
dc.subject.keywordPlus | DNA DELIVERY | - |
dc.subject.keywordPlus | ATHEROSCLEROSIS | - |
dc.subject.keywordPlus | MAGNETOFECTION | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordPlus | PROSPECTS | - |
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