Hybrid superparamagnetic iron oxide nanoparticle-branched polyethylenimine magnetoplexes for gene transfection of vascular endothelial cells

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The work demonstrated the development of thermally cross-linked superparamagnetic nanomaterial which possessed polyethylene glycol moiety and covalently linked branched polyethylenimine (BPEI), and exhibited highly efficient magnetofection even under serum conditioned media. The study showed its high anti-biofouling, cell viability and serum stability and thus revealed a potential magnetic nanoparticle-mediated targeted gene delivery system. This superparamagnetic particle mediated rapid and efficient transfection in primary vascular endothelial cells (HUVEC) successfully inhibits expression of PAI-1 which is responsible for various vascular dysfunctions such as vascular inflammation and atherosclerosis and thereby provides a potential strategy to transfect highly sensitive HUVEC. The sequential steps for the enhanced magnetofection had been studied by monitoring cellular uptake with the aid of confocal microscopy.
Publisher
ELSEVIER SCI LTD
Issue Date
2010-05
Language
English
Article Type
Article
Keywords

BIODEGRADABLE POLYMERIC NANOPARTICLES; IN-VIVO; THERAPY PROGRESS; MAGNETIC FORCE; DNA DELIVERY; ATHEROSCLEROSIS; MAGNETOFECTION; TRANSDUCTION; ULTRASOUND; PROSPECTS

Citation

BIOMATERIALS, v.31, no.14, pp.4204 - 4213

ISSN
0142-9612
DOI
10.1016/j.biomaterials.2010.01.123
URI
http://hdl.handle.net/10203/192404
Appears in Collection
BS-Journal Papers(저널논문)
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