DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Mi Kyung | ko |
dc.contributor.author | Park, Jinho | ko |
dc.contributor.author | Jeong, Yong Yeon | ko |
dc.contributor.author | Moon, Woo Kyung | ko |
dc.contributor.author | Jon, Sangyong | ko |
dc.date.accessioned | 2014-12-09T01:28:39Z | - |
dc.date.available | 2014-12-09T01:28:39Z | - |
dc.date.created | 2014-08-29 | - |
dc.date.created | 2014-08-29 | - |
dc.date.issued | 2010-10 | - |
dc.identifier.citation | NANOTECHNOLOGY, v.21, no.41 | - |
dc.identifier.issn | 0957-4484 | - |
dc.identifier.uri | http://hdl.handle.net/10203/192400 | - |
dc.description.abstract | We report multifunctional nanoparticles that are capable of cancer targeting and simultaneous cancer imaging and therapy. The nanoparticles are composed of cyclic arginine-glycine-aspartic acid (cRGD) peptide ligand bioconjugated thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) that enable loading of the anticancer drug doxorubicin (Dox). The cyclic RGD-conjugated TCL-SPION (cRGD_TCL-SPION) had a mean hydrodynamic size of 34 +/- 8 nm with approximately 0.39 wt% of cyclic RGD attached to the surface of the nanoparticles. The cRGD_TCL-SPION exhibited preferential binding towards target cancer cells (U87MG, integrin alpha(v)beta(3)+) when analyzed by T(2)- weighted magnetic resonance (MR) imaging. When Dox was loaded onto the polymeric coating layers of cRGD_TCL-SPION via ionic interaction, the resulting Dox-loaded cRGD TCL-SPION (Dox@cRGD_TCL-SPION) showed much higher cytotoxicity in U87MG cells than Dox@TCL-SPION lacking cRGD (IC(50) value of 0.02 mu M versus 0.12 mu M). These results suggest that Dox@cRGD_TCL-SPION has potential for use as an integrin-targeted, combined imaging and therapeutic agent. | - |
dc.language | English | - |
dc.publisher | IOP PUBLISHING LTD | - |
dc.subject | MULTIFUNCTIONAL MAGNETIC NANOPARTICLES | - |
dc.subject | IN-VIVO | - |
dc.subject | QUANTUM DOTS | - |
dc.subject | TUMOR VASCULATURE | - |
dc.subject | BREAST-CANCER | - |
dc.subject | CONTRAST AGENTS | - |
dc.subject | RGD PEPTIDES | - |
dc.subject | CELLS | - |
dc.subject | ALPHA(V)BETA(3) | - |
dc.subject | PROBE | - |
dc.title | Integrin-targeting thermally cross-linked superparamagnetic iron oxide nanoparticles for combined cancer imaging and drug delivery | - |
dc.type | Article | - |
dc.identifier.wosid | 000281958600004 | - |
dc.type.rims | ART | - |
dc.citation.volume | 21 | - |
dc.citation.issue | 41 | - |
dc.citation.publicationname | NANOTECHNOLOGY | - |
dc.contributor.localauthor | Jon, Sangyong | - |
dc.contributor.nonIdAuthor | Yu, Mi Kyung | - |
dc.contributor.nonIdAuthor | Park, Jinho | - |
dc.contributor.nonIdAuthor | Jeong, Yong Yeon | - |
dc.contributor.nonIdAuthor | Moon, Woo Kyung | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | MULTIFUNCTIONAL MAGNETIC NANOPARTICLES | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | QUANTUM DOTS | - |
dc.subject.keywordPlus | TUMOR VASCULATURE | - |
dc.subject.keywordPlus | BREAST-CANCER | - |
dc.subject.keywordPlus | CONTRAST AGENTS | - |
dc.subject.keywordPlus | RGD PEPTIDES | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | ALPHA(V)BETA(3) | - |
dc.subject.keywordPlus | PROBE | - |
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