Integrin-targeting thermally cross-linked superparamagnetic iron oxide nanoparticles for combined cancer imaging and drug delivery

Cited 53 time in webofscience Cited 0 time in scopus
  • Hit : 130
  • Download : 0
DC FieldValueLanguage
dc.contributor.authorYu, Mi Kyungko
dc.contributor.authorPark, Jinhoko
dc.contributor.authorJeong, Yong Yeonko
dc.contributor.authorMoon, Woo Kyungko
dc.contributor.authorJon, Sangyongko
dc.date.accessioned2014-12-09T01:28:39Z-
dc.date.available2014-12-09T01:28:39Z-
dc.date.created2014-08-29-
dc.date.created2014-08-29-
dc.date.issued2010-10-
dc.identifier.citationNANOTECHNOLOGY, v.21, no.41-
dc.identifier.issn0957-4484-
dc.identifier.urihttp://hdl.handle.net/10203/192400-
dc.description.abstractWe report multifunctional nanoparticles that are capable of cancer targeting and simultaneous cancer imaging and therapy. The nanoparticles are composed of cyclic arginine-glycine-aspartic acid (cRGD) peptide ligand bioconjugated thermally cross-linked superparamagnetic iron oxide nanoparticles (TCL-SPION) that enable loading of the anticancer drug doxorubicin (Dox). The cyclic RGD-conjugated TCL-SPION (cRGD_TCL-SPION) had a mean hydrodynamic size of 34 +/- 8 nm with approximately 0.39 wt% of cyclic RGD attached to the surface of the nanoparticles. The cRGD_TCL-SPION exhibited preferential binding towards target cancer cells (U87MG, integrin alpha(v)beta(3)+) when analyzed by T(2)- weighted magnetic resonance (MR) imaging. When Dox was loaded onto the polymeric coating layers of cRGD_TCL-SPION via ionic interaction, the resulting Dox-loaded cRGD TCL-SPION (Dox@cRGD_TCL-SPION) showed much higher cytotoxicity in U87MG cells than Dox@TCL-SPION lacking cRGD (IC(50) value of 0.02 mu M versus 0.12 mu M). These results suggest that Dox@cRGD_TCL-SPION has potential for use as an integrin-targeted, combined imaging and therapeutic agent.-
dc.languageEnglish-
dc.publisherIOP PUBLISHING LTD-
dc.subjectMULTIFUNCTIONAL MAGNETIC NANOPARTICLES-
dc.subjectIN-VIVO-
dc.subjectQUANTUM DOTS-
dc.subjectTUMOR VASCULATURE-
dc.subjectBREAST-CANCER-
dc.subjectCONTRAST AGENTS-
dc.subjectRGD PEPTIDES-
dc.subjectCELLS-
dc.subjectALPHA(V)BETA(3)-
dc.subjectPROBE-
dc.titleIntegrin-targeting thermally cross-linked superparamagnetic iron oxide nanoparticles for combined cancer imaging and drug delivery-
dc.typeArticle-
dc.identifier.wosid000281958600004-
dc.type.rimsART-
dc.citation.volume21-
dc.citation.issue41-
dc.citation.publicationnameNANOTECHNOLOGY-
dc.contributor.localauthorJon, Sangyong-
dc.contributor.nonIdAuthorYu, Mi Kyung-
dc.contributor.nonIdAuthorPark, Jinho-
dc.contributor.nonIdAuthorJeong, Yong Yeon-
dc.contributor.nonIdAuthorMoon, Woo Kyung-
dc.type.journalArticleArticle-
dc.subject.keywordPlusMULTIFUNCTIONAL MAGNETIC NANOPARTICLES-
dc.subject.keywordPlusIN-VIVO-
dc.subject.keywordPlusQUANTUM DOTS-
dc.subject.keywordPlusTUMOR VASCULATURE-
dc.subject.keywordPlusBREAST-CANCER-
dc.subject.keywordPlusCONTRAST AGENTS-
dc.subject.keywordPlusRGD PEPTIDES-
dc.subject.keywordPlusCELLS-
dc.subject.keywordPlusALPHA(V)BETA(3)-
dc.subject.keywordPlusPROBE-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
There are no files associated with this item.
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 53 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0