Immunological Activities of Cationic Methylan Derivatives

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Methylan polysaccharide was aminated to add dialkylaminoethyl and free amino groups at hydroxyl sites in the methylan backbone, and these derivatives were quaternized to produce pH-independent cationic polyelectrolytes. The immunological activities of the resulting methylan derivatives were investigated. Diethylaminoethyl (DEAE)-methylan derivatives inhibited the classical pathway of the complement system in a dose-dependent way. Quatemized DEAE-methylan exhibited the highest anticomplementary activities among the all derivatives. Anticomplementary activities increased significantly as the cationic charge of the methylan derivatives increased via aminoderivatization followed by quaternization, indicating that there is an electrostatic interaction between the methylan derivatives and the negatively charged functional residues on the cell.
Publisher
KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
Issue Date
2014-06
Language
English
Article Type
Article
Keywords

POLYSACCHARIDE

Citation

JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.57, no.3, pp.319 - 321

ISSN
1738-2203
DOI
10.1007/s13765-013-4312-1
URI
http://hdl.handle.net/10203/190146
Appears in Collection
BS-Journal Papers(저널논문)
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