DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chang, Ki-Young | ko |
dc.contributor.author | Woo, Doyeon | ko |
dc.contributor.author | Jung, Hyunjin | ko |
dc.contributor.author | Lee, Sangkyu | ko |
dc.contributor.author | Kim, Sungsoo | ko |
dc.contributor.author | Won, Joungha | ko |
dc.contributor.author | Kyung, Taeyoon | ko |
dc.contributor.author | Park, Hye Rim | ko |
dc.contributor.author | Kim, Nury | ko |
dc.contributor.author | Yang, Hee Won | ko |
dc.contributor.author | Park, Jae-Yong | ko |
dc.contributor.author | Hwang, Eun Mi | ko |
dc.contributor.author | Kim, Daesoo | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.date.accessioned | 2014-09-02T02:36:05Z | - |
dc.date.available | 2014-09-02T02:36:05Z | - |
dc.date.created | 2014-06-23 | - |
dc.date.created | 2014-06-23 | - |
dc.date.created | 2014-06-23 | - |
dc.date.created | 2014-06-23 | - |
dc.date.issued | 2014-06 | - |
dc.identifier.citation | NATURE COMMUNICATIONS, v.5, pp.4057 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/10203/189866 | - |
dc.description.abstract | Receptor tyrosine kinases (RTKs) are a family of cell-surface receptors that have a key role in regulating critical cellular processes. Here, to understand and precisely control RTK signalling, we report the development of a genetically encoded, photoactivatable Trk (tropomyosin-related kinase) family of RTKs using a light-responsive module based on Arabidopsis thaliana cryptochrome 2. Blue-light stimulation (488 nm) of mammalian cells harbouring these receptors robustly upregulates canonical Trk signalling. A single light stimulus triggers transient signalling activation, which is reversibly tuned by repetitive delivery of blue-light pulses. In addition, the light-provoked process is induced in a spatially restricted and cell-specific manner. A prolonged patterned illumination causes sustained activation of extracellular signal-regulated kinase and promotes neurite outgrowth in a neuronal cell line, and induces filopodia formation in rat hippocampal neurons. These light-controllable receptors are expected to create experimental opportunities to spatiotemporally manipulate many biological processes both in vitro and in vivo. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Light-inducible receptor tyrosine kinases that regulate neurotrophin signalling | - |
dc.type | Article | - |
dc.identifier.wosid | 000338838000001 | - |
dc.identifier.scopusid | 2-s2.0-84901992638 | - |
dc.type.rims | ART | - |
dc.citation.volume | 5 | - |
dc.citation.beginningpage | 4057 | - |
dc.citation.publicationname | NATURE COMMUNICATIONS | - |
dc.identifier.doi | 10.1038/ncomms5057 | - |
dc.contributor.localauthor | Kim, Daesoo | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.nonIdAuthor | Chang, Ki-Young | - |
dc.contributor.nonIdAuthor | Woo, Doyeon | - |
dc.contributor.nonIdAuthor | Jung, Hyunjin | - |
dc.contributor.nonIdAuthor | Lee, Sangkyu | - |
dc.contributor.nonIdAuthor | Kim, Sungsoo | - |
dc.contributor.nonIdAuthor | Kim, Nury | - |
dc.contributor.nonIdAuthor | Yang, Hee Won | - |
dc.contributor.nonIdAuthor | Park, Jae-Yong | - |
dc.contributor.nonIdAuthor | Hwang, Eun Mi | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | NERVE GROWTH-FACTOR | - |
dc.subject.keywordPlus | PROTEIN INTERACTIONS | - |
dc.subject.keywordPlus | TRK RECEPTORS | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | CELLS | - |
dc.subject.keywordPlus | TRANSDUCTION | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | PARTNERS | - |
dc.subject.keywordPlus | LIGAND | - |
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