DC Field | Value | Language |
---|---|---|
dc.contributor.author | Choi, Hyun-Sook | ko |
dc.contributor.author | Kim, Hana | ko |
dc.contributor.author | Lee, Chang Gook | ko |
dc.contributor.author | Kim, Young Mi | ko |
dc.contributor.author | Lee, Younghoon | ko |
dc.date.accessioned | 2014-09-01T08:41:54Z | - |
dc.date.available | 2014-09-01T08:41:54Z | - |
dc.date.created | 2014-03-12 | - |
dc.date.created | 2014-03-12 | - |
dc.date.issued | 2014-01 | - |
dc.identifier.citation | BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.1, pp.83 - 86 | - |
dc.identifier.issn | 0253-2964 | - |
dc.identifier.uri | http://hdl.handle.net/10203/189671 | - |
dc.description.abstract | Poly(A) polymerase (PAP) play an essential role for maturation of mRNA by adding the adenylate residues at the 3' end. PAP functions are regulated through protein-protein interaction at its C-terminal region. In this study, cyclophilin A (CypA), a member of the peptidyl-prolyl cis-trans isomerase family, was identified as a partner protein interacting with the C-terminal region PAP. The interaction between PAP and CypA was inhibited by the immunosuppressive drug cyclosporine A. Deletion analysis revealed that the N-terminal 56 residues of CypA are sufficient for the interaction with PAP. Interestingly, we observed that PAP and CypA colocalize in the nucleus during SDF-1-induced chemotaxis, implying that CypA could be involved in the regulation of polyadenylation by PAP in the chemotactic cells. | - |
dc.language | English | - |
dc.publisher | KOREAN CHEMICAL SOC | - |
dc.subject | CIS-TRANS-ISOMERASES | - |
dc.subject | CYCLOSPORINE-A | - |
dc.subject | MESSENGER-RNA | - |
dc.subject | CYTOPLASMIC POLYADENYLATION | - |
dc.subject | CARBOXYL-TERMINUS | - |
dc.subject | BINDING-PROTEIN | - |
dc.subject | COMPLEX | - |
dc.subject | TRANSLATION | - |
dc.subject | EUKARYOTES | - |
dc.subject | MECHANISM | - |
dc.title | Protein-Protein Interaction between Poly(A) Polymerase and Cyclophilin A in Chemotactic Cells | - |
dc.type | Article | - |
dc.identifier.wosid | 000330682100013 | - |
dc.identifier.scopusid | 2-s2.0-84892918207 | - |
dc.type.rims | ART | - |
dc.citation.volume | 35 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 83 | - |
dc.citation.endingpage | 86 | - |
dc.citation.publicationname | BULLETIN OF THE KOREAN CHEMICAL SOCIETY | - |
dc.identifier.doi | 10.5012/bkcs.2014.35.1.83 | - |
dc.contributor.localauthor | Lee, Younghoon | - |
dc.contributor.nonIdAuthor | Kim, Hana | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Poly(A) polymerase (PAP) | - |
dc.subject.keywordAuthor | Cyclophilin A (CypA) | - |
dc.subject.keywordAuthor | Protein-protein interaction | - |
dc.subject.keywordAuthor | Stromal cell-derived factor-1 (SDF-1) | - |
dc.subject.keywordAuthor | Chemotactic cells | - |
dc.subject.keywordPlus | CIS-TRANS-ISOMERASES | - |
dc.subject.keywordPlus | CYCLOSPORINE-A | - |
dc.subject.keywordPlus | MESSENGER-RNA | - |
dc.subject.keywordPlus | CYTOPLASMIC POLYADENYLATION | - |
dc.subject.keywordPlus | CARBOXYL-TERMINUS | - |
dc.subject.keywordPlus | BINDING-PROTEIN | - |
dc.subject.keywordPlus | COMPLEX | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | EUKARYOTES | - |
dc.subject.keywordPlus | MECHANISM | - |
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