Neurons on nanometric topographies: insights into neuronal behaviors in vitro

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dc.contributor.authorKim, Miheeko
dc.contributor.authorPark, Matthew Yko
dc.contributor.authorKang, Kyung Taeko
dc.contributor.authorChoi, Insungko
dc.date.accessioned2014-09-01T08:21:32Z-
dc.date.available2014-09-01T08:21:32Z-
dc.date.created2014-02-24-
dc.date.created2014-02-24-
dc.date.issued2014-02-
dc.identifier.citationBIOMATERIALS SCIENCE, v.2, no.2, pp.148 - 155-
dc.identifier.issn2047-4830-
dc.identifier.urihttp://hdl.handle.net/10203/189479-
dc.description.abstractTopography, the physical characteristics of an environment, is one of the most prominent stimuli neurons can encounter in the body. Many aspects of neurons and neuronal behavior are affected by the size, shape, and pattern of the physical features of the environment. A recent increase in the use of nanometric topographies, due to improved fabrication techniques, has resulted in new findings on neuronal behavior and development. Factors such as neuron adhesion, neurite alignment, and even the rate of neurite formation have all been highlighted through nanotopographies as complex phenomena that are driven by intricate intracellular mechanisms. Nanotopographies are suitable platforms, not only for fundamental studies on neuronal development, but also in practical applications, including multielectrode array devices and neuro-regenerative medicine. We reviewed recent publications that address the effects of nanotopography on neurons and categorized the observed behaviors as adherence, directional guidance, or accelerated outgrowth. We also discussed possible biological mechanisms of the molecular and cellular responses to topography, and suggested future perspectives for this field.-
dc.languageEnglish-
dc.publisherROYAL SOC CHEMISTRY-
dc.subjectSCALE SURFACE TOPOGRAPH-
dc.subjectNITRIDE TIN FILMS-
dc.subjectHIPPOCAMPAL-NEURONS-
dc.subjectNEURITE OUTGROWTH-
dc.subjectCONTACT GUIDANCE-
dc.subjectCARBON NANOTUBES-
dc.subjectPOROUS SILICON-
dc.subjectELECTROSPUN NANOFIBERS-
dc.subjectAXONAL OUTGROWTH-
dc.subjectNEURAL CELLS-
dc.titleNeurons on nanometric topographies: insights into neuronal behaviors in vitro-
dc.typeArticle-
dc.identifier.wosid000330177700001-
dc.identifier.scopusid2-s2.0-84891420780-
dc.type.rimsART-
dc.citation.volume2-
dc.citation.issue2-
dc.citation.beginningpage148-
dc.citation.endingpage155-
dc.citation.publicationnameBIOMATERIALS SCIENCE-
dc.identifier.doi10.1039/c3bm60255a-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorChoi, Insung-
dc.type.journalArticleReview-
dc.subject.keywordPlusSCALE SURFACE TOPOGRAPH-
dc.subject.keywordPlusNITRIDE TIN FILMS-
dc.subject.keywordPlusHIPPOCAMPAL-NEURONS-
dc.subject.keywordPlusNEURITE OUTGROWTH-
dc.subject.keywordPlusCONTACT GUIDANCE-
dc.subject.keywordPlusCARBON NANOTUBES-
dc.subject.keywordPlusPOROUS SILICON-
dc.subject.keywordPlusELECTROSPUN NANOFIBERS-
dc.subject.keywordPlusAXONAL OUTGROWTH-
dc.subject.keywordPlusNEURAL CELLS-
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