DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Young-Soon | ko |
dc.contributor.author | Kang, Won-Seok | ko |
dc.contributor.author | Chang, Dong-Yeop | ko |
dc.contributor.author | Sung, Pil-Soo | ko |
dc.contributor.author | Park, Bum-Chan | ko |
dc.contributor.author | Yoo, Seok-Ho | ko |
dc.contributor.author | Park, Young-Woo | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.date.accessioned | 2014-09-01T07:44:10Z | - |
dc.date.available | 2014-09-01T07:44:10Z | - |
dc.date.created | 2014-01-27 | - |
dc.date.created | 2014-01-27 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | CLINICAL IMMUNOLOGY, v.149, no.3, pp.379 - 387 | - |
dc.identifier.issn | 1521-6616 | - |
dc.identifier.uri | http://hdl.handle.net/10203/189339 | - |
dc.description.abstract | We investigated regulation of human NK cell function by CD27 engagement using a recombinant soluble CD70 protein. CD27 was preferentially expressed on CD56(bright) NK cells, and soluble CD70 protein bound to CD27(+)CD56(bright) NK cells. While soluble CD70 protein enhanced secretion by CD56(bright) NK cells in the presence of IL-12, it augmented neither cytolytic activity nor proliferation of NK cells. Thus, we next asked if soluble CD70 protein could be used to induce non-cytolytic antiviral activity of NK cells using an in vitro hepatitis C virus (HCV) infection system. Soluble CD70 protein stimulated NK cells to suppress HCV replication by enhancing NK cell IFN-gamma secretion without killing infected cells. Taken together, we demonstrate that CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56(bright) NK cells by IFN-gamma secretion. Thus, this soluble CD70 protein may be useful for the treatment of viral infections such as HCV infection. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | CHRONIC HEPATITIS-C | - |
dc.subject | RECOMBINANT HUMAN INTERLEUKIN-12 | - |
dc.subject | VIRUS-INFECTION | - |
dc.subject | IMMUNE-RESPONSE | - |
dc.subject | PLUS RIBAVIRIN | - |
dc.subject | NK-CELLS | - |
dc.subject | SUBSETS | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | ACTIVATION | - |
dc.subject | RECEPTORS | - |
dc.title | CD27 engagement by a soluble CD70 protein enhances non-cytolytic antiviral activity of CD56(bright) natural killer cells by IFN-gamma secretion | - |
dc.type | Article | - |
dc.identifier.wosid | 000328874800003 | - |
dc.identifier.scopusid | 2-s2.0-84887261442 | - |
dc.type.rims | ART | - |
dc.citation.volume | 149 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 379 | - |
dc.citation.endingpage | 387 | - |
dc.citation.publicationname | CLINICAL IMMUNOLOGY | - |
dc.identifier.doi | 10.1016/j.clim.2013.09.007 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Sung, Pil-Soo | - |
dc.contributor.nonIdAuthor | Park, Bum-Chan | - |
dc.contributor.nonIdAuthor | Yoo, Seok-Ho | - |
dc.contributor.nonIdAuthor | Park, Young-Woo | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | Natural killpr cells | - |
dc.subject.keywordAuthor | CD27 | - |
dc.subject.keywordAuthor | CD70 | - |
dc.subject.keywordAuthor | IFN-gamma | - |
dc.subject.keywordAuthor | Hepatitis C virus | - |
dc.subject.keywordPlus | CHRONIC HEPATITIS-C | - |
dc.subject.keywordPlus | RECOMBINANT HUMAN INTERLEUKIN-12 | - |
dc.subject.keywordPlus | VIRUS-INFECTION | - |
dc.subject.keywordPlus | IMMUNE-RESPONSE | - |
dc.subject.keywordPlus | PLUS RIBAVIRIN | - |
dc.subject.keywordPlus | NK-CELLS | - |
dc.subject.keywordPlus | SUBSETS | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | RECEPTORS | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.