Cytoskeletal Actin Dynamics are Involved in Pitch-Dependent Neurite Outgrowth on Bead Monolayers

Cited 45 time in webofscience Cited 38 time in scopus
  • Hit : 585
  • Download : 39
Neurite outgrowth is an important preceding step for the development of nerve systems. Given that the in vivo environments of neurons consist of numerous hierarchical micro/nanotopographies, there have been many efforts to investigate the relationship between neuronal behaviors and surface topography. The acceleration of neurite outgrowth was recently reported on surfaces with a periodic nanotopography, but the biological mechanism has not yet been elucidated. In this work, the initial neurite development of hippocampal neurons on assembled silica beads with diameters ranging from 700 to 1800 nm was explored. The acceleration of neurite outgrowth increased with the surface-pitch size and leveled off after a pitch of 1 mm. Biochemical analysis indicated that cytoskeletal actin dynamics were primarily responsible for the recognition of surface topography. This work contributes to the emerging research field of topographical neurochemistry, as well as applied fields including neuroregeneration and neuroprosthetics.
Publisher
WILEY-V C H VERLAG GMBH
Issue Date
2014-06
Language
English
Article Type
Article
Citation

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, v.53, no.24, pp.6075 - 6079

ISSN
1433-7851
DOI
10.1002/anie.201400653
URI
http://hdl.handle.net/10203/189284
Appears in Collection
BiS-Journal Papers(저널논문)CH-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 45 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0