Variable allelic expression of imprinted genes in human pluripotent stem cells during differentiation into specialized cell types in vitro

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dc.contributor.authorPark, Sang-Wookko
dc.contributor.authorKim, Jihoonko
dc.contributor.authorPark, Jong-Lyulko
dc.contributor.authorKo, Ji-Yunko
dc.contributor.authorIm, Ilkyunko
dc.contributor.authorDo, Hyo-Sangko
dc.contributor.authorKim, Hyeminko
dc.contributor.authorNgoc-Tung Tranko
dc.contributor.authorLee, Sang-Hunko
dc.contributor.authorKim, Yong Sungko
dc.contributor.authorCho, Yee Sookko
dc.contributor.authorLee, Dong Ryulko
dc.contributor.authorHan, Yong-Mahnko
dc.date.accessioned2014-08-29T04:21:20Z-
dc.date.available2014-08-29T04:21:20Z-
dc.date.created2014-06-03-
dc.date.created2014-06-03-
dc.date.issued2014-04-
dc.identifier.citationBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.446, no.2, pp.493 - 498-
dc.identifier.issn0006-291X-
dc.identifier.urihttp://hdl.handle.net/10203/189062-
dc.description.abstractGenomic imprinting is an epigenetic phenomenon by which a subset of genes is asymmetrically expressed in a parent-of-origin manner. However, little is known regarding the epigenetic behaviors of imprinted genes during human development. Here, we show dynamic epigenetic changes in imprinted genes in hESCs during in vitro differentiation into specialized cell types. Out of 9 imprinted genes with single nucleotide polymorphisms, mono-allelic expression for three imprinted genes (H19, KCNQ10T1, and IPW), and bi- or partial-allelic expression for three imprinted genes (OSBPL5, PPP1R9A, and RTL1) were stably retained in H9-hESCs throughout differentiation, representing imprinting stability. Three imprinted genes (KCNK9, ATP10A, and SLC22A3) showed a loss and a gain of imprinting in a lineage-specific manner during differentiation. Changes in allelic expression of imprinted genes were observed in another hESC line during in vitro differentiation. These findings indicate that the allelic expression of imprinted genes may be vulnerable in a lineage-specific manner in human pluripotent stem cells during differentiation.-
dc.languageEnglish-
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE-
dc.subjectDNA METHYLATION-
dc.subjectGENOME-
dc.subjectMOUSE-
dc.subjectCLUSTERS-
dc.subjectLINES-
dc.titleVariable allelic expression of imprinted genes in human pluripotent stem cells during differentiation into specialized cell types in vitro-
dc.typeArticle-
dc.identifier.wosid000334902600013-
dc.identifier.scopusid2-s2.0-84898017708-
dc.type.rimsART-
dc.citation.volume446-
dc.citation.issue2-
dc.citation.beginningpage493-
dc.citation.endingpage498-
dc.citation.publicationnameBIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS-
dc.identifier.doi10.1016/j.bbrc.2014.02.141-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorHan, Yong-Mahn-
dc.contributor.nonIdAuthorPark, Sang-Wook-
dc.contributor.nonIdAuthorKim, Jihoon-
dc.contributor.nonIdAuthorPark, Jong-Lyul-
dc.contributor.nonIdAuthorKo, Ji-Yun-
dc.contributor.nonIdAuthorIm, Ilkyun-
dc.contributor.nonIdAuthorKim, Hyemin-
dc.contributor.nonIdAuthorNgoc-Tung Tran-
dc.contributor.nonIdAuthorLee, Sang-Hun-
dc.contributor.nonIdAuthorKim, Yong Sung-
dc.contributor.nonIdAuthorCho, Yee Sook-
dc.contributor.nonIdAuthorLee, Dong Ryul-
dc.type.journalArticleArticle-
dc.subject.keywordAuthorHuman pluripotent stem cells-
dc.subject.keywordAuthorIn vitro differentiation-
dc.subject.keywordAuthorImprinted genes-
dc.subject.keywordAuthorAllele-specific expression-
dc.subject.keywordPlusDNA METHYLATION-
dc.subject.keywordPlusGENOME-
dc.subject.keywordPlusMOUSE-
dc.subject.keywordPlusCLUSTERS-
dc.subject.keywordPlusLINES-
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