Cell-repellant Dextran Coatings of Porous Titania Using Mussel Adhesion Chemistry

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dc.contributor.authorPark, Jae Yoonko
dc.contributor.authorYeom, Jihyeonko
dc.contributor.authorKim, Jee Seonko
dc.contributor.authorLee, Mihyunko
dc.contributor.authorLee, Haeshinko
dc.contributor.authorNam, YoonSungko
dc.date.accessioned2014-08-29T01:20:16Z-
dc.date.available2014-08-29T01:20:16Z-
dc.date.created2014-01-20-
dc.date.created2014-01-20-
dc.date.created2014-01-20-
dc.date.created2014-01-20-
dc.date.issued2013-11-
dc.identifier.citationMACROMOLECULAR BIOSCIENCE, v.13, no.11, pp.1511 - 1519-
dc.identifier.issn1616-5187-
dc.identifier.urihttp://hdl.handle.net/10203/188746-
dc.description.abstractThe resistance of bioceramics against non-specific adsorption of serum proteins is critical for a wide range of biomedical applications. Some polysaccharides serve as natural protein-resistant molecules in extracellular matrices; however, the stable adhesion of polysaccharides to ceramic biomaterials in an aqueous solution is very challenging because chemical linkages at organic/inorganic interfaces are susceptible to hydrolytic degradation. Here, a catechol-grafted dextran, which strongly binds to titania (TiO2) in an aqueous milieu to effectively suppress cell adhesion through anti-fouling activity against non-specific protein adsorption, is introduced. Catechol is conjugated approximately to 6.7 mol% of glucose units of dextran via a carbamate ester linkage, corresponding to roughly three catechols per dextran chain having an average molecular weight of 6kDa. Multivalent interactions of catechols with a titanium atom, enabled by the graft-type structure, provide a very stable coating of dextran on this inorganic surface. The adhesion of HeLa cells on the dextran-coated titania surface is reduced by 2.4-fold compared to that on a pristine titania surface. These results suggest that the graft-type incorporation of a small number of catechol moieties along a dextran backbone is an effective means of producing a stable anti-fouling interface on inorganic biomaterials in an aqueous environment.-
dc.languageEnglish-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.titleCell-repellant Dextran Coatings of Porous Titania Using Mussel Adhesion Chemistry-
dc.typeArticle-
dc.identifier.wosid000328320300005-
dc.identifier.scopusid2-s2.0-84887824489-
dc.type.rimsART-
dc.citation.volume13-
dc.citation.issue11-
dc.citation.beginningpage1511-
dc.citation.endingpage1519-
dc.citation.publicationnameMACROMOLECULAR BIOSCIENCE-
dc.identifier.doi10.1002/mabi.201300224-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorYeom, Jihyeon-
dc.contributor.localauthorLee, Haeshin-
dc.contributor.localauthorNam, YoonSung-
dc.contributor.nonIdAuthorPark, Jae Yoon-
dc.description.isOpenAccessN-
dc.type.journalArticleArticle-
dc.subject.keywordAuthoranti-fouling-
dc.subject.keywordAuthorcatechol-
dc.subject.keywordAuthorcell adhesion-
dc.subject.keywordAuthordextran-
dc.subject.keywordAuthortitanium dioxide-
dc.subject.keywordPlusBOVINE SERUM-ALBUMIN-
dc.subject.keywordPlusPROTEIN ADSORPTION-
dc.subject.keywordPlusPOLY(ETHYLENE GLYCOL)-
dc.subject.keywordPlusMETALLIC BIOMATERIALS-
dc.subject.keywordPlusIN-VITRO-
dc.subject.keywordPlusSURFACES-
dc.subject.keywordPlusRELEASE-
dc.subject.keywordPlusTIO2-
dc.subject.keywordPlusNANOPARTICLES-
dc.subject.keywordPlusDEGRADATION-
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