DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yoshimatsu, Yasuhiro | ko |
dc.contributor.author | Lee, Yulia G. | ko |
dc.contributor.author | Akatsu, Yuichi | ko |
dc.contributor.author | Taguchi, Luna | ko |
dc.contributor.author | Suzuki, Hiroshi I. | ko |
dc.contributor.author | Cunha, Sara I. | ko |
dc.contributor.author | Maruyama, Kazuichi | ko |
dc.contributor.author | Suzuki, Yuka | ko |
dc.contributor.author | Yamazaki, Tomoko | ko |
dc.contributor.author | Katsura, Akihiro | ko |
dc.contributor.author | Oh, S. Paul | ko |
dc.contributor.author | Zimmers, Teresa A. | ko |
dc.contributor.author | Lee, Se-Jin | ko |
dc.contributor.author | Pietras, Kristian | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Miyazono, Kohei | ko |
dc.contributor.author | Watabe, Tetsuro | ko |
dc.date.accessioned | 2014-08-29 | - |
dc.date.available | 2014-08-29 | - |
dc.date.created | 2013-12-16 | - |
dc.date.created | 2013-12-16 | - |
dc.date.issued | 2013-11 | - |
dc.identifier.citation | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, v.110, no.47, pp.18940 - 18945 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10203/188607 | - |
dc.description.abstract | Lymphatic vessels (LVs) play critical roles in the maintenance of fluid homeostasis and in pathological conditions, including cancer metastasis. Although mutations in ALK1, a member of the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) receptor family, have been linked to hereditary hemorrhagic telangiectasia, a human vascular disease, the roles of activin receptor-like kinase 1(ALK-1) signals in LV formation largely remain to be elucidated. We show that ALK-1 signals inhibit LV formation, and LVs were enlarged in multiple organs in Alk1-depleted mice. These inhibitory effects of ALK-1 signaling were mediated by BMP-9, which decreased the number of cultured lymphatic endothelial cells. Bmp9-deficient mouse embryos consistently exhibited enlarged dermal LVs. BMP-9 also inhibited LV formation during inflammation and tumorigenesis. BMP-9 downregulated the expression of the transcription factor prospero-related homeobox 1, which is necessary to maintain lymphatic endothelial cell identity. Furthermore, silencing prospero-related homeobox 1 expression inhibited lymphatic endothelial cell proliferation. Our findings reveal a unique molecular basis for the physiological and pathological roles of BMP-9/ALK-1 signals in LV formation. | - |
dc.language | English | - |
dc.publisher | NATL ACAD SCIENCES | - |
dc.subject | HEMORRHAGIC TELANGIECTASIA TYPE-2 | - |
dc.subject | ENDOTHELIAL-CELL | - |
dc.subject | LYMPHANGIOGENESIS | - |
dc.subject | ALK1 | - |
dc.subject | PROX1 | - |
dc.subject | ANGIOGENESIS | - |
dc.subject | MUTATIONS | - |
dc.subject | PHENOTYPE | - |
dc.subject | GROWTH | - |
dc.subject | BMP-9 | - |
dc.title | Bone morphogenetic protein-9 inhibits lymphatic vessel formation via activin receptor-like kinase 1 during development and cancer progression | - |
dc.type | Article | - |
dc.identifier.wosid | 000327100600059 | - |
dc.identifier.scopusid | 2-s2.0-84888084861 | - |
dc.type.rims | ART | - |
dc.citation.volume | 110 | - |
dc.citation.issue | 47 | - |
dc.citation.beginningpage | 18940 | - |
dc.citation.endingpage | 18945 | - |
dc.citation.publicationname | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | - |
dc.identifier.doi | 10.1073/pnas.1310479110 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.nonIdAuthor | Yoshimatsu, Yasuhiro | - |
dc.contributor.nonIdAuthor | Lee, Yulia G. | - |
dc.contributor.nonIdAuthor | Akatsu, Yuichi | - |
dc.contributor.nonIdAuthor | Taguchi, Luna | - |
dc.contributor.nonIdAuthor | Suzuki, Hiroshi I. | - |
dc.contributor.nonIdAuthor | Cunha, Sara I. | - |
dc.contributor.nonIdAuthor | Maruyama, Kazuichi | - |
dc.contributor.nonIdAuthor | Suzuki, Yuka | - |
dc.contributor.nonIdAuthor | Yamazaki, Tomoko | - |
dc.contributor.nonIdAuthor | Katsura, Akihiro | - |
dc.contributor.nonIdAuthor | Oh, S. Paul | - |
dc.contributor.nonIdAuthor | Zimmers, Teresa A. | - |
dc.contributor.nonIdAuthor | Lee, Se-Jin | - |
dc.contributor.nonIdAuthor | Pietras, Kristian | - |
dc.contributor.nonIdAuthor | Miyazono, Kohei | - |
dc.contributor.nonIdAuthor | Watabe, Tetsuro | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | lymphangiogenesis | - |
dc.subject.keywordAuthor | angiogenesis | - |
dc.subject.keywordAuthor | blood vascular endothelial cells | - |
dc.subject.keywordPlus | HEMORRHAGIC TELANGIECTASIA TYPE-2 | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELL | - |
dc.subject.keywordPlus | LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | ALK1 | - |
dc.subject.keywordPlus | PROX1 | - |
dc.subject.keywordPlus | ANGIOGENESIS | - |
dc.subject.keywordPlus | MUTATIONS | - |
dc.subject.keywordPlus | PHENOTYPE | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | BMP-9 | - |
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