DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Kyuri | ko |
dc.contributor.author | Ryu, Ji Hyun | ko |
dc.contributor.author | Lee, Dong Yun | ko |
dc.contributor.author | Lee, Haeshin | ko |
dc.date.accessioned | 2014-08-28 | - |
dc.date.available | 2014-08-28 | - |
dc.date.created | 2013-07-17 | - |
dc.date.created | 2013-07-17 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | BIOMATERIALS SCIENCE, v.1, no.7, pp.783 - 790 | - |
dc.identifier.issn | 2047-4830 | - |
dc.identifier.uri | http://hdl.handle.net/10203/187451 | - |
dc.description.abstract | This report describes a simple method to prepare water-soluble chitosan derivative by conjugation of an enediol group, catechol. Chitosan functionalized with a catechol-containing compound, 3,4-dihydroxy-hydrocinnamic acid, by a carbodiimide coupling method resulted in chitosan-catechol conjugates. This one-step chemical modification of high-molecular-weight chitosan (approximately 100 kDa) dramatically increased the water solubility of the chitosan derivative to 60 mg mL(-1) at pH 7.0. The degree of catechol conjugation was found critical in determining the solubility. The chitosan-catechol conjugates are not only water-soluble but are adhesive, due to the intrinsic adhesive properties of catechol. Also, the water-soluble chitosan derivative allows one to directly form chitosan hydrogel in neutral buffer solutions. The utility of both the water solubility and the adhesive property of the chitosan-catechol was demonstrated by the effective layer-by-layer assembly on substrates. The water-soluble chitosan-catechol is expected to be useful in many areas of surface functionalization, drug delivery, tissue engineering, and tissue adhesives. | - |
dc.language | English | - |
dc.publisher | ROYAL SOC CHEMISTRY | - |
dc.subject | GLYCOL CHITOSAN | - |
dc.subject | POLY(ETHYLENE GLYCOL) | - |
dc.subject | MOLECULAR-WEIGHT | - |
dc.subject | SURFACE | - |
dc.subject | SOLUBILITY | - |
dc.subject | POLYMER | - |
dc.subject | ACID | - |
dc.subject | BIODISTRIBUTION | - |
dc.subject | ACETYLATION | - |
dc.subject | PEGYLATION | - |
dc.title | Bio-inspired catechol conjugation converts water-insoluble chitosan into a highly water-soluble, adhesive chitosan derivative for hydrogels and LbL assembly | - |
dc.type | Article | - |
dc.identifier.wosid | 000330136100011 | - |
dc.identifier.scopusid | 2-s2.0-84883230992 | - |
dc.type.rims | ART | - |
dc.citation.volume | 1 | - |
dc.citation.issue | 7 | - |
dc.citation.beginningpage | 783 | - |
dc.citation.endingpage | 790 | - |
dc.citation.publicationname | BIOMATERIALS SCIENCE | - |
dc.identifier.doi | 10.1039/c3bm00004d | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Lee, Haeshin | - |
dc.contributor.nonIdAuthor | Kim, Kyuri | - |
dc.contributor.nonIdAuthor | Ryu, Ji Hyun | - |
dc.contributor.nonIdAuthor | Lee, Dong Yun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | GLYCOL CHITOSAN | - |
dc.subject.keywordPlus | POLY(ETHYLENE GLYCOL) | - |
dc.subject.keywordPlus | MOLECULAR-WEIGHT | - |
dc.subject.keywordPlus | SURFACE | - |
dc.subject.keywordPlus | SOLUBILITY | - |
dc.subject.keywordPlus | POLYMER | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | BIODISTRIBUTION | - |
dc.subject.keywordPlus | ACETYLATION | - |
dc.subject.keywordPlus | PEGYLATION | - |
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