DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Jeon Yeob | ko |
dc.contributor.author | Koh, Young Jun | ko |
dc.contributor.author | Lee, Seung-Hun | ko |
dc.contributor.author | Lee, Junyeop | ko |
dc.contributor.author | Kim, Kyoo Hyun | ko |
dc.contributor.author | Kim, Daesoo | ko |
dc.contributor.author | Koh, Gou Young | ko |
dc.contributor.author | Yoo, Ook-Joon | ko |
dc.date.accessioned | 2014-08-27T02:29:52Z | - |
dc.date.available | 2014-08-27T02:29:52Z | - |
dc.date.created | 2013-11-01 | - |
dc.date.created | 2013-11-01 | - |
dc.date.issued | 2013-09 | - |
dc.identifier.citation | BLOOD, v.122, no.13, pp.2151 - 2161 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.uri | http://hdl.handle.net/10203/187374 | - |
dc.description.abstract | To unveil the organotypic role and vulnerability of lymphatic vessels, we generated a lymphatic vessel endothelial hyaluronan receptor-1 (LYVE-1)-Cre/iDTR double-transgenic mouse and ablated LYVE-1-expressing lymphatic vessels in adult mice in a diphtheria toxin (DT)-inducible manner based on selective expression of LYVE-1 in most lymphatic vessels. Strikingly, lymphatic vessels in the small intestine and lymph nodes were rapidly ablated, but lymphatic vessels in the other organs were relatively intact at 24 hours after DT administration. Unexpectedly, LYVE-1-Cre/iDTR mice died of sepsis without visible edema at 24 and 60 hours after DT administration. The cause of death appeared to be related to acute failure of immune surveillance systemsin the small intestine and draining lymph nodes. Of note, acute loss of lymphatic lacteals in intestinal villi appeared to trigger distortion of blood capillaries and the whole architecture of the villi, whereas acute loss of lymphatic vessels in lymph nodes caused dysfunction of lymph drainage and abnormal distribution of dendritic cells andmacrophages. Thus, intact lymphatic vessels are required for structural and functionalmaintenance of surrounding tissues in an organotypicmanner, at least in the intestine and lymph nodes. | - |
dc.language | English | - |
dc.publisher | AMER SOC HEMATOLOGY | - |
dc.subject | HYALURONAN RECEPTOR LYVE-1 | - |
dc.subject | CELL-LINEAGE-ABLATION | - |
dc.subject | INFLAMMATORY LYMPHANGIOGENESIS | - |
dc.subject | CD11B(+) MACROPHAGES | - |
dc.subject | ENDOTHELIAL-CELLS | - |
dc.subject | IMMUNE-SYSTEM | - |
dc.subject | PEYERS-PATCH | - |
dc.subject | IN-VIVO | - |
dc.subject | VASCULATURE | - |
dc.subject | TISSUE | - |
dc.title | Conditional ablation of LYVE-1+cells unveils defensive roles of lymphatic vessels in intestine and lymph nodes | - |
dc.type | Article | - |
dc.identifier.wosid | 000325269900006 | - |
dc.identifier.scopusid | 2-s2.0-84887344625 | - |
dc.type.rims | ART | - |
dc.citation.volume | 122 | - |
dc.citation.issue | 13 | - |
dc.citation.beginningpage | 2151 | - |
dc.citation.endingpage | 2161 | - |
dc.citation.publicationname | BLOOD | - |
dc.identifier.doi | 10.1182/blood-2013-01-478941 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Daesoo | - |
dc.contributor.localauthor | Koh, Gou Young | - |
dc.contributor.localauthor | Yoo, Ook-Joon | - |
dc.contributor.nonIdAuthor | Jang, Jeon Yeob | - |
dc.contributor.nonIdAuthor | Koh, Young Jun | - |
dc.contributor.nonIdAuthor | Lee, Seung-Hun | - |
dc.contributor.nonIdAuthor | Lee, Junyeop | - |
dc.contributor.nonIdAuthor | Kim, Kyoo Hyun | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | HYALURONAN RECEPTOR LYVE-1 | - |
dc.subject.keywordPlus | CELL-LINEAGE-ABLATION | - |
dc.subject.keywordPlus | INFLAMMATORY LYMPHANGIOGENESIS | - |
dc.subject.keywordPlus | CD11B(+) MACROPHAGES | - |
dc.subject.keywordPlus | ENDOTHELIAL-CELLS | - |
dc.subject.keywordPlus | IMMUNE-SYSTEM | - |
dc.subject.keywordPlus | PEYERS-PATCH | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | VASCULATURE | - |
dc.subject.keywordPlus | TISSUE | - |
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