DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Su-Hyung | ko |
dc.contributor.author | Veerapu, Naga Suresh | ko |
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Biancotto, Angelique | ko |
dc.contributor.author | McCoy, J. Philip | ko |
dc.contributor.author | Capone, Stefania | ko |
dc.contributor.author | Folgori, Antonella | ko |
dc.contributor.author | Rehermann, Barbara | ko |
dc.date.accessioned | 2014-08-26T08:18:18Z | - |
dc.date.available | 2014-08-26T08:18:18Z | - |
dc.date.created | 2014-02-16 | - |
dc.date.created | 2014-02-16 | - |
dc.date.created | 2014-02-16 | - |
dc.date.created | 2014-02-16 | - |
dc.date.issued | 2013-12 | - |
dc.identifier.citation | NATURE MEDICINE, v.19, no.12, pp.1638 - 1642 | - |
dc.identifier.issn | 1078-8956 | - |
dc.identifier.uri | http://hdl.handle.net/10203/187082 | - |
dc.description.abstract | Hepatitis C virus (HCV) is endemic in many countries due to its high propensity for establishing persistence(1). The presence of HCV-specific T cells in subjects repeatedly exposed to HCV who test negative for HCV RNA and antibodies and who do not have any history of HCV infection has been interpreted as T cell-mediated protection(2-5). Here, we show in nonhuman primates that repeated exposure to human plasma with trace amounts of HCV induced HCV-specific T cells without seroconversion and systemic viremia but did not protect upon subsequent HCV challenge. Rather, HCV-specific recall and de novo T cell responses, as well as intrahepatic T cell recruitment and interferon-gamma (IFN-gamma) production, were suppressed upon HCV challenge, concomitant with quantitative and qualitative changes in regulatory T cells (T-reg cells) that occurred after subinfectious HCV exposure and increased after HCV challenge. In vitro T-reg cell depletion restored HCV-specific T cell responses. Thus, T cells primed by trace amounts of HCV do not generate effective recall responses upon subsequent HCV infection. Subinfectious HCV exposure predisposes to T-reg cell expansion, which suppresses effector T cells during subsequent infection. Strategies to reverse this exposure-induced immune suppression should be examined to aid in the development of T cell-based vaccines against HCV and other endemic pathogens. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.title | Subinfectious hepatitis C virus exposures suppress T cell responses against subsequent acute infection | - |
dc.type | Article | - |
dc.identifier.wosid | 000328181400033 | - |
dc.identifier.scopusid | 2-s2.0-84889885286 | - |
dc.type.rims | ART | - |
dc.citation.volume | 19 | - |
dc.citation.issue | 12 | - |
dc.citation.beginningpage | 1638 | - |
dc.citation.endingpage | 1642 | - |
dc.citation.publicationname | NATURE MEDICINE | - |
dc.identifier.doi | 10.1038/nm.3408 | - |
dc.contributor.localauthor | Park, Su-Hyung | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Veerapu, Naga Suresh | - |
dc.contributor.nonIdAuthor | Biancotto, Angelique | - |
dc.contributor.nonIdAuthor | McCoy, J. Philip | - |
dc.contributor.nonIdAuthor | Capone, Stefania | - |
dc.contributor.nonIdAuthor | Folgori, Antonella | - |
dc.contributor.nonIdAuthor | Rehermann, Barbara | - |
dc.description.isOpenAccess | N | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | INJECTION-DRUG USERS | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | REGULATORY CELLS | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | RECOVERED CHIMPANZEES | - |
dc.subject.keywordPlus | MEMORY | - |
dc.subject.keywordPlus | HCV | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordPlus | SEROCONVERSION | - |
dc.subject.keywordPlus | RECHALLENGE | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.