DC Field | Value | Language |
---|---|---|
dc.contributor.author | Woo, Jooyeon | ko |
dc.contributor.author | Kwon, Seok-Kyu | ko |
dc.contributor.author | Choi, Seungwon | ko |
dc.contributor.author | Kim, Seho | ko |
dc.contributor.author | Lee, Jae-Ran | ko |
dc.contributor.author | Dunah, Anthone W. | ko |
dc.contributor.author | Sheng, Morgan | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2010-05-27T05:09:54Z | - |
dc.date.available | 2010-05-27T05:09:54Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-04 | - |
dc.identifier.citation | NATURE NEUROSCIENCE, v.12, no.4, pp.428 - 437 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.uri | http://hdl.handle.net/10203/18588 | - |
dc.description.abstract | Synaptic adhesion molecules regulate multiple steps of synapse formation and maturation. The great diversity of neuronal synapses predicts the presence of a large number of adhesion molecules that control synapse formation through trans-synaptic and heterophilic adhesion. We identified a previously unknown trans-synaptic interaction between netrin-G ligand-3 (NGL-3), a postsynaptic density (PSD) 95-interacting postsynaptic adhesion molecule, and leukocyte common antigen-related (LAR), a receptor protein tyrosine phosphatase. NGL-3 and LAR expressed in heterologous cells induced pre-and postsynaptic differentiation in contacting axons and dendrites of cocultured rat hippocampal neurons, respectively. Neuronal overexpression of NGL-3 increased presynaptic contacts on dendrites of transfected neurons. Direct aggregation of NGL-3 on dendrites induced coclustering of excitatory postsynaptic proteins. Knockdown of NGL-3 reduced the number and function of excitatory synapses. Competitive inhibition by soluble LAR reduced NGL-3-induced presynaptic differentiation. These results suggest that the trans-synaptic adhesion between NGL-3 and LAR regulates excitatory synapse formation in a bidirectional manner. | - |
dc.description.sponsorship | This work was supported by the National Creative Research Initiative Program of the Korean Ministry of Science and Technology (E.K.). | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject | LIPRIN-ALPHA | - |
dc.subject | NEURITE OUTGROWTH | - |
dc.subject | NERVOUS-SYSTEM | - |
dc.subject | BETA-NEUREXINS | - |
dc.subject | RECEPTOR | - |
dc.subject | LIGAND | - |
dc.subject | MOLECULES | - |
dc.subject | NETRIN | - |
dc.subject | DIFFERENTIATION | - |
dc.title | Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses | - |
dc.type | Article | - |
dc.identifier.wosid | 000264563100017 | - |
dc.identifier.scopusid | 2-s2.0-63649101646 | - |
dc.type.rims | ART | - |
dc.citation.volume | 12 | - |
dc.citation.issue | 4 | - |
dc.citation.beginningpage | 428 | - |
dc.citation.endingpage | 437 | - |
dc.citation.publicationname | NATURE NEUROSCIENCE | - |
dc.identifier.doi | 10.1038/nn.2279 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Lee, Jae-Ran | - |
dc.contributor.nonIdAuthor | Dunah, Anthone W. | - |
dc.contributor.nonIdAuthor | Sheng, Morgan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | PROTEIN-TYROSINE-PHOSPHATASE | - |
dc.subject.keywordPlus | LIPRIN-ALPHA | - |
dc.subject.keywordPlus | NEURITE OUTGROWTH | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | BETA-NEUREXINS | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | LIGAND | - |
dc.subject.keywordPlus | MOLECULES | - |
dc.subject.keywordPlus | NETRIN | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
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