IDENTIFICATION OF INHIBITORY METABOLITES IN HIGH-DENSITY CULTURE OF RECOMBINANT BACILLUS-MEGATERIUM PCK108
Propionic and isobutyric acids were found to be the major inhibitory metabolites for carboxymethyl(CM)-cellulase in high density culture of a recombinant Bacillus megaterium pCK108. These organic acids accumulated significantly at the glucose feed rate of 12g/hr. They inhibited CM-cellulase production by about 80% even at 20mM and 10mM of propionic and isobutyric acids, respectively.
- Publisher
- CHAPMAN HALL LTD
- Issue Date
- 1994-10
- Language
- English
- Article Type
- Article
- Keywords
ESCHERICHIA-COLI; GROWTH; BATCH
- Citation
BIOTECHNOLOGY LETTERS, v.16, no.10, pp.1011 - 1014
- ISSN
- 0141-5492
- Appears in Collection
- BS-Journal Papers(저널논문)
- Files in This Item
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