The influence of dynamical medium depletion in high-order above-threshold ionization (ATI) in left/right asymmetry of photoelectron energy spectra is analyzed. Based on a classical analysis of high-order ATI electrons produced by few-cycle laser pulses, calculated asymmetry maps of electron spectra reproduce very well the experimental results reported in Lindner [Phys. Rev. Lett. 92, 113001 (2004)], utilized for determining the Guoy phase shift of few-cycle laser pulses. The anomalous behavior of the high-energy part of the ATI electron spectra is, then, fully understood in terms of earlier medium depletion occurring in the leading edge of the laser pulse. In order to correctly reproduce the experimental findings a physical temporal envelope of the laser pulse, which only vanishes at the infinity, plays a crucial role.