Recently, there has been considerable interest in the idea of cross-layer design of wireless networks. This is motivated by the need to provide a greater level of adaptivity to variations of wireless channels. This thesis suggest one aspect of the interaction between the physical and medium access control layers. In particular, we consider the design considerations of MAC protocols that are tailored for the Multipacket Reception. In this thesis we focus on the design considerations of MAC protocols that are tailored for MPR and find conditions of the throughput arising from reusing legacy MAC protocols in networks with spatially distributed nodes.