DC Field | Value | Language |
---|---|---|
dc.contributor.advisor | Kim, Jong-Duk | - |
dc.contributor.advisor | 김종득 | - |
dc.contributor.author | Yoon, Se-Rim | - |
dc.contributor.author | 윤세림 | - |
dc.date.accessioned | 2013-09-11T01:08:08Z | - |
dc.date.available | 2013-09-11T01:08:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.uri | http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=487394&flag=dissertation | - |
dc.identifier.uri | http://hdl.handle.net/10203/180006 | - |
dc.description | 학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2012.2, [ viii, 59 p. ] | - |
dc.description.abstract | Charge-converting poly (amino acid)s derivative in response to acidic tumor environment was successfully derived. PHEA-g-C18 with a charge-converting property was designed by two significant steps, starting from polyaspartamide (PHEA) and including: (1) introduction of ethylenediamine groups via urethanic linkage; and (2) attachment of Dimethylmaleic acid (DMMA) in a basic condition. The obtained polymer had been verified to form a stable spherical micelle via TEM image, forming a well-defined structure, yet degrades well with the presence of proteolytic enzymes. The zeta potential value had converted from negatively-charged to positively-charged when it meets the acidic tumor extracellular environment. The results indicate that the charge conversion behavior would increase the cellular uptake, and moreover, decrease the unwanted protein adsorption under neutral condition. These proper-ties can further be applied as an early detecting module of cancer and become an advanced study of designing smart drug carriers for drug and gene delivery. | eng |
dc.language | eng | - |
dc.publisher | 한국과학기술원 | - |
dc.subject | 약물전달체 | - |
dc.subject | 폴리아미노산 | - |
dc.subject | pH 민감성 고분자 | - |
dc.subject | drug delivery carrier | - |
dc.subject | poly(amino acid)s | - |
dc.subject | pH-sensitive polymers | - |
dc.subject | amphiphilic graft polymer | - |
dc.subject | 양친성 고분자 | - |
dc.title | Charge conversional poly(amino acid)s derivatives as a drug delivery carrier in response to the tumor environment | - |
dc.title.alternative | 암세포의 산성환경에 따라 전하가 특이적으로 바뀌는 폴리아미노산 유도체를 이용한 약물 전달체의 응용연구 | - |
dc.type | Thesis(Master) | - |
dc.identifier.CNRN | 487394/325007 | - |
dc.description.department | 한국과학기술원 : 생명화학공학과, | - |
dc.identifier.uid | 020103417 | - |
dc.contributor.localauthor | Kim, Jong-Duk | - |
dc.contributor.localauthor | 김종득 | - |
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