Size and morphology control of aggregates from supramolecular graft copolymers stabilized by ionic interaction = 이온결합으로 안정화된 초분자 그라프트 공중합체를 이용한 자기조립체의 크기와 형태조절에 관한 연구

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A series of supramolecular graft copolymers (SGPs) composed of $Poly(_L-lysine)$ (PLL) as a main chain and $poly(_{D,L}-lactic-co-glycolic acid)$ (PLGA) as a side chain was synthesized with different degrees of substitution (DSs) through ionic interaction in a DMSO solvent. The addition of water induced the self-assembly of PLL-PLGA SPGs into spherical micelles at a critical water content (CWC). The size of the spherical micelles at each CWC decreased with an increase of DS and core-shell structures, which was confirmed by XPS and zeta-potential measurements. The morphological transitions were driven under thermodynamic control when the solvents mixed. Consequently, further increases of water content caused the transition of the spherical mi-celles to vesicles, while the initial spherical micelles were reconstructed from vesicles when the DMSO was added. The content of water, the boundaries for the morphology transition, depended on the DS. The pH and salt levels affected the stability of the aggregates weakening the ionic interactions between the PLL and PLGA.
Advisors
Kim, Jong-Dukresearcher김종득researcher
Description
한국과학기술원 : 생명화학공학과,
Publisher
한국과학기술원
Issue Date
2011
Identifier
467722/325007  / 020093518
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 생명화학공학과, 2011.2, [ vi, 52 p. ]

Keywords

graft copolymers; morphology; self-assembly; stimuli-sensitive polymers; 그라프트 공중합체; 모폴로지; 자기조립; 자극감응성 고분자; 초분자 구조; supramolecular structures

URI
http://hdl.handle.net/10203/179957
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=467722&flag=dissertation
Appears in Collection
CBE-Theses_Master(석사논문)
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