비정형 결여성 뇌전증 동물모델에서 사회적 행동 연구 = Study of social behavior in an animal model of atypical absence epilepsy

Cited 0 time in webofscience Cited 0 time in scopus
  • Hit : 750
  • Download : 0
Absence epilepsy is characterized by a distinct spike-and-wave discharge (SWD) in the electroencephalogram (EEG). Unlike the typical form of absence epilepsy, atypical absence epilepsy (AAE) showing slow SWD (<3 Hz) is characterized by severely abnormal cognition and neurodevelopmental or neurological outcomes in humans. Plus, only thalamocortical circuitry is involved in the typical form of absence epilepsy, whereas AAE is known to involve limbic circuitry including hippocampus as well as thalamocortical circuitry. However, despite the severe cognitive and neurodevelopmental outcomes in AAE, the relationship between AAE and social-behavioral dysfunctions has not been defined well, either experimentally or in patients with AAE. In this study, we characterized social behaviors in the mouse model of AAE.AAE in the mouse was induced by repeated postnatal administration of AY-9944 (AY), a cholesterol biosynthesis inhibitor, every 6 days from postnatal day (P) 2 to P20. SWD was investigated in frontal cortex, parietal cortex, and hippocampus by long-term video-EEG monitoring. AY-treated mice performed various social behavior tests such as sociability/social novelty preference, social interaction with a juvenile conspecific, observational fear, and resident-intruder aggression. As a result, AY-treated mice exhibited spontaneous, recurrent, and synchronous SWD. The average frequency of SWD was 4-5 Hz in EEG recordings. Furthermore, AY-treated mice showed behavioral dysfunction in social interactions with a juvenile conspecific, sociability/social novelty preference, and social fear learning tests. AY-treated mice also exhibited increased levels of offensive behaviors in a resident-intruder test. Together, these results suggest abnormal epileptic activity during postnatal development and severely altered social behaviors in AY-9944 model, which may help to reveal neural mechanisms underlying AAE. This study can provide novel and valuable information about brain dise...
Advisors
Jeon, Dae-Jongresearcher전대종
Description
한국과학기술원 : 바이오및뇌공학과,
Publisher
한국과학기술원
Issue Date
2013
Identifier
514960/325007  / 020113566
Language
eng
Description

학위논문(석사) - 한국과학기술원 : 바이오및뇌공학과, 2013.2, [ v, 21 p. ]

Keywords

Atypical absence epilepsy; Behavioral comorbidities; Social behavior; AY-9944; 비정형 결여성 뇌전증; 행동학적 동시이환; 사회적 행동; AY-9944; 레녹스 게스타우트 신드롬; Lennox-Gastaut syndrome

URI
http://hdl.handle.net/10203/179725
Link
http://library.kaist.ac.kr/search/detail/view.do?bibCtrlNo=514960&flag=dissertation
Appears in Collection
BiS-Theses_Master(석사논문)
Files in This Item
There are no files associated with this item.

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0