DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Junil | ko |
dc.contributor.author | Park, Sang-Min | ko |
dc.contributor.author | Cho, Kwang-Hyun | ko |
dc.date.accessioned | 2013-08-22T02:22:09Z | - |
dc.date.available | 2013-08-22T02:22:09Z | - |
dc.date.created | 2013-07-15 | - |
dc.date.created | 2013-07-15 | - |
dc.date.issued | 2013-07 | - |
dc.identifier.citation | SCIENTIFIC REPORTS, v.3 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | http://hdl.handle.net/10203/175496 | - |
dc.description.abstract | Cellular behavior is determined not by a single molecule but by many molecules that interact strongly with one another and form a complex network. It is unclear whether cellular behavior can be controlled by regulating certain molecular components in the network. By analyzing a variety of biomolecular regulatory networks, we discovered that only a small fraction of the network components need to be regulated to govern the network dynamics and control cellular behavior. We defined a minimal set of network components that must be regulated to make the cell reach a desired stable state as the control kernel and developed a general algorithm for identifying it. We found that the size of the control kernel was related to both the topological and logical characteristics of a network. Intriguingly, the control kernel of the human signaling network included many drug targets and chemical-binding interactions, suggesting therapeutic application of the control kernel. | - |
dc.language | English | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | EVOLUTIONARY DESIGN PRINCIPLES | - |
dc.subject | BIOLOGICAL NETWORKS | - |
dc.subject | SIGNAL-TRANSDUCTION | - |
dc.subject | COMPLEX NETWORKS | - |
dc.subject | FEEDBACK LOOPS | - |
dc.subject | PATHWAYS | - |
dc.subject | ROBUSTNESS | - |
dc.subject | TRANSITION | - |
dc.subject | TARGETS | - |
dc.subject | MODULES | - |
dc.title | Discovery of a kernel for controlling biomolecular regulatory networks | - |
dc.type | Article | - |
dc.identifier.wosid | 000321890000008 | - |
dc.identifier.scopusid | 2-s2.0-84880347253 | - |
dc.type.rims | ART | - |
dc.citation.volume | 3 | - |
dc.citation.publicationname | SCIENTIFIC REPORTS | - |
dc.identifier.doi | 10.1038/srep02223 | - |
dc.contributor.localauthor | Cho, Kwang-Hyun | - |
dc.contributor.nonIdAuthor | Kim, Junil | - |
dc.contributor.nonIdAuthor | Park, Sang-Min | - |
dc.description.isOpenAccess | Y | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | EVOLUTIONARY DESIGN PRINCIPLES | - |
dc.subject.keywordPlus | BIOLOGICAL NETWORKS | - |
dc.subject.keywordPlus | SIGNAL-TRANSDUCTION | - |
dc.subject.keywordPlus | COMPLEX NETWORKS | - |
dc.subject.keywordPlus | FEEDBACK LOOPS | - |
dc.subject.keywordPlus | PATHWAYS | - |
dc.subject.keywordPlus | ROBUSTNESS | - |
dc.subject.keywordPlus | TRANSITION | - |
dc.subject.keywordPlus | TARGETS | - |
dc.subject.keywordPlus | MODULES | - |
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