DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeong, Won-il | ko |
dc.contributor.author | Do, Sun-Hee | ko |
dc.contributor.author | Jeong, Da-Hee | ko |
dc.contributor.author | Hong, Il-Hwa | ko |
dc.contributor.author | Park, Jin-Kyu | ko |
dc.contributor.author | Ran, Ki-Mi | ko |
dc.contributor.author | Yang, Hai-Jie | ko |
dc.contributor.author | Yuan, Dong-Wei | ko |
dc.contributor.author | Kim, Soon-Bok | ko |
dc.contributor.author | Cha, Myung-Sook | ko |
dc.contributor.author | Jeong, Kyu-Shik | ko |
dc.date.accessioned | 2010-04-06T02:10:27Z | - |
dc.date.available | 2010-04-06T02:10:27Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2006-09 | - |
dc.identifier.citation | ANTICANCER RESEARCH, v.26, no.5A, pp.3517 - 3526 | - |
dc.identifier.issn | 0250-7005 | - |
dc.identifier.uri | http://hdl.handle.net/10203/17546 | - |
dc.description.abstract | Background: The involvement of whether macrophages and mast cells in the kinetics of matrix metalloproteinases-1 (MMP-1), MMP-3 and MMP-9, tissue inhibitors of metalloproteinases-1 (TIMP-1) and TIMP-2 in hepatic fibrosis/cirrhosis was examined. Materials and Methods: The MMPs and TIMPs were examined by histopathology, immunohistochemistry and immunoblotting using carbon tetra chloride-induced fibrotic rat liver. Results: MMP-1 increased in proportion to the development of fibrosis and reached maximum at week 14. In the first four weeks, MMP-3 expression was mainly observed in many hepatocytes. At week 8, the macrophages in the fibrous septa, as well as hepatocytes, expressed MMP-3. TIMP-1 and -2 progressively increased throughout the experimental periods. The MMP-1 expression in the mast cells, however, did not decrease the degree of liver cirrhosis. Conclusion: MMP-1, TIMP-1 and -2 expressions increased in the late stages of fibrosis and cirrhosis. During recovery, the MMP-3 expression of macrophages greatly increased in the unresolved fibrous septa. | - |
dc.description.sponsorship | This work presented in this paper was supported by the Kyungpook National University Research Team Fund in 2002 and the Brain Korea 21 Project in 2006. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Int Inst Anticancer Research | - |
dc.subject | HEPATIC LIPOCYTES SYNTHESIZE | - |
dc.subject | HUMAN ALVEOLAR MACROPHAGES | - |
dc.subject | CIRRHOTIC HUMAN LIVER | - |
dc.subject | MATRIX METALLOPROTEINASES | - |
dc.subject | TISSUE INHIBITOR | - |
dc.subject | INTERSTITIAL COLLAGENASE | - |
dc.subject | ATHEROSCLEROTIC PLAQUES | - |
dc.subject | STELLATE CELLS | - |
dc.subject | EXPRESSION | - |
dc.subject | FIBROSIS | - |
dc.title | Kinetics of MMP-1 and MMP-3 produced by mast cells and macrophages in liver fibrogenesis of rat | - |
dc.type | Article | - |
dc.identifier.wosid | 000241707300046 | - |
dc.identifier.scopusid | 2-s2.0-33750717503 | - |
dc.type.rims | ART | - |
dc.citation.volume | 26 | - |
dc.citation.issue | 5A | - |
dc.citation.beginningpage | 3517 | - |
dc.citation.endingpage | 3526 | - |
dc.citation.publicationname | ANTICANCER RESEARCH | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Jeong, Won-il | - |
dc.contributor.nonIdAuthor | Do, Sun-Hee | - |
dc.contributor.nonIdAuthor | Jeong, Da-Hee | - |
dc.contributor.nonIdAuthor | Hong, Il-Hwa | - |
dc.contributor.nonIdAuthor | Park, Jin-Kyu | - |
dc.contributor.nonIdAuthor | Ran, Ki-Mi | - |
dc.contributor.nonIdAuthor | Yang, Hai-Jie | - |
dc.contributor.nonIdAuthor | Yuan, Dong-Wei | - |
dc.contributor.nonIdAuthor | Kim, Soon-Bok | - |
dc.contributor.nonIdAuthor | Cha, Myung-Sook | - |
dc.contributor.nonIdAuthor | Jeong, Kyu-Shik | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | MMP-1 | - |
dc.subject.keywordAuthor | MMP-3 | - |
dc.subject.keywordAuthor | macrophage | - |
dc.subject.keywordAuthor | mast cell | - |
dc.subject.keywordAuthor | fibrosis | - |
dc.subject.keywordPlus | HEPATIC LIPOCYTES SYNTHESIZE | - |
dc.subject.keywordPlus | HUMAN ALVEOLAR MACROPHAGES | - |
dc.subject.keywordPlus | CIRRHOTIC HUMAN LIVER | - |
dc.subject.keywordPlus | MATRIX METALLOPROTEINASES | - |
dc.subject.keywordPlus | TISSUE INHIBITOR | - |
dc.subject.keywordPlus | INTERSTITIAL COLLAGENASE | - |
dc.subject.keywordPlus | ATHEROSCLEROTIC PLAQUES | - |
dc.subject.keywordPlus | STELLATE CELLS | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | FIBROSIS | - |
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