DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jin Woo | ko |
dc.contributor.author | Chang, Tong-Shin | ko |
dc.contributor.author | Lee, Ji Eun | ko |
dc.contributor.author | Huh, Sung-Ho | ko |
dc.contributor.author | Yeon, Seung Woo | ko |
dc.contributor.author | Yang, Wan Seok | ko |
dc.contributor.author | Joe, Cheol O. | ko |
dc.contributor.author | Mook-Jung, Inhee | ko |
dc.contributor.author | Tanzi, Rudolph E. | ko |
dc.contributor.author | Kim, Tae-Wan | ko |
dc.contributor.author | Joe, Cheol O | ko |
dc.date.accessioned | 2010-04-05T02:15:00Z | - |
dc.date.available | 2010-04-05T02:15:00Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2001-04 | - |
dc.identifier.citation | JOURNAL OF CELL BIOLOGY, v.153, no.3, pp.457 - 463 | - |
dc.identifier.issn | 0021-9525 | - |
dc.identifier.uri | http://hdl.handle.net/10203/17520 | - |
dc.description.abstract | Presenilin 1 (PS1) plays a pivotal role in Notch signaling and the intracellular metabolism of the amyloid beta -protein, To understand intracellular signaling events downstream of PSI, we investigated in this study the action of PS1 on mitogen-activated protein kinase pathways. Overexpressed PS1 suppressed the stress-induced stimulation of stress-activated protein kinase (SAPK)/c-Jun NH2-terminal kinase (JNK) in human embryonic kidney 293 cells. Interestingly, two functionally inactive PSI mutants, PS1(D257A) and PS1(D385A), failed to inhibit UV-stimulated SAPK/ JNK. Furthermore, H2O2- or UV-stimulated SAPK activity was higher in mouse embryonic fibroblast (MEF) cells from PS1-null mice than in MEF cells from PS+/+ mice. MEFPS1(-/-) cells were more sensitive to the H2O2-induced apoptosis than MEFPS1(+/+) cells. Ectopic expression of PS1 in MEFPS1(-/-) cells suppressed H2O2-stimulated SAPK/JNK activity and apoptotic cell death. Together, our data suggest that PS1 inhibits the stress-activated signaling by suppressing the SAPK/ JNK pathway. | - |
dc.description.sponsorship | a National Creative Research Initiative Center for Cell Death, Graduate School of Biotechnology, Korea University, Seoul, 136-701, Korea b Brain Disease Research Center, Ajou University School of Medicine, Suwon, Kyongki-do, Korea c Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Taejon, 305-701, Korea d Genetics and Aging Research Unit, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | ROCKEFELLER UNIV PRESS | - |
dc.subject | FAMILIAL ALZHEIMERS-DISEASE | - |
dc.subject | AMYLOID PRECURSOR PROTEIN | - |
dc.subject | MAP KINASES | - |
dc.subject | MISSENSE MUTATIONS | - |
dc.subject | INDUCED APOPTOSIS | - |
dc.subject | MAMMALIAN-CELLS | - |
dc.subject | GENE | - |
dc.subject | NOTCH | - |
dc.subject | JNK | - |
dc.subject | STRESS | - |
dc.title | Negative regulation of the SAPK/JNK signaling pathway by presenilin 1 | - |
dc.type | Article | - |
dc.identifier.wosid | 000168481400003 | - |
dc.identifier.scopusid | 2-s2.0-0035809240 | - |
dc.type.rims | ART | - |
dc.citation.volume | 153 | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 457 | - |
dc.citation.endingpage | 463 | - |
dc.citation.publicationname | JOURNAL OF CELL BIOLOGY | - |
dc.identifier.doi | 10.1083/jcb.153.3.457 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Jin Woo | - |
dc.contributor.localauthor | Joe, Cheol O | - |
dc.contributor.nonIdAuthor | Chang, Tong-Shin | - |
dc.contributor.nonIdAuthor | Lee, Ji Eun | - |
dc.contributor.nonIdAuthor | Huh, Sung-Ho | - |
dc.contributor.nonIdAuthor | Yeon, Seung Woo | - |
dc.contributor.nonIdAuthor | Yang, Wan Seok | - |
dc.contributor.nonIdAuthor | Joe, Cheol O. | - |
dc.contributor.nonIdAuthor | Mook-Jung, Inhee | - |
dc.contributor.nonIdAuthor | Tanzi, Rudolph E. | - |
dc.contributor.nonIdAuthor | Kim, Tae-Wan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | apoptosis | - |
dc.subject.keywordAuthor | c-Jun NH2-terminal kinase | - |
dc.subject.keywordAuthor | presenilin 1 | - |
dc.subject.keywordAuthor | gamma-secretase | - |
dc.subject.keywordAuthor | stress-activated protein kinase | - |
dc.subject.keywordPlus | FAMILIAL ALZHEIMERS-DISEASE | - |
dc.subject.keywordPlus | AMYLOID PRECURSOR PROTEIN | - |
dc.subject.keywordPlus | MAP KINASES | - |
dc.subject.keywordPlus | MISSENSE MUTATIONS | - |
dc.subject.keywordPlus | INDUCED APOPTOSIS | - |
dc.subject.keywordPlus | MAMMALIAN-CELLS | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordPlus | NOTCH | - |
dc.subject.keywordPlus | JNK | - |
dc.subject.keywordPlus | STRESS | - |
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