This paper is concerned with the failure load of the spot weld under combined axial and shear loading conditions. The testing fixture and the specimen are newly designed to impose the combined axial and shear load on the spot weld. Using the proposed testing fixtures and specimens, failure tests of the spot weld are conducted with seven different combined loading conditions. Based on the experimental results, failure loads and failure behaviors of the spot weld are investigated with respect to different loading angles. Failure loads of the spot weld obtained from failure tests are interpolated to construct the empirical engineering failure model, which facilitates the failure description of the spot weld in the macroscopic FE analysis of the structural members.