DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Yunhee | ko |
dc.contributor.author | Lee, Mira | ko |
dc.contributor.author | Kim, Semi | ko |
dc.date.accessioned | 2013-08-08T06:03:23Z | - |
dc.date.available | 2013-08-08T06:03:23Z | - |
dc.date.created | 2013-06-18 | - |
dc.date.created | 2013-06-18 | - |
dc.date.issued | 2013-04 | - |
dc.identifier.citation | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, v.434, no.1, pp.8 - 14 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10203/174822 | - |
dc.description.abstract | Binding of Gas6 to Axl (Gas6/Axl axis) alters cellular functions, including migration, invasion, proliferation, and survival. However, the molecular mechanisms underlying Gas6-mediated cell migration remain poorly understood. In this study, we found that Gas6 induced the activation of JNK and ERK1/2 signaling in cancer cells expressing Axl, resulting in the phosphorylation of activator protein-1 (AP-1) transcription factors c-Jun and ATF-2, and induction of Slug. Depletion of c-Jun or ATF-2 by siRNA attenuated the Gas6-induced expression of Slug. Slug expression was required for cell migration and E-cadherin reduction/vimentin induction induced by Gas6. These results suggest that Gas6 induced cell migration via Slug upregulation in JNK- and ERK1/2-dependent mechanisms. These data provide an important insight into the molecular mechanisms mediating Gas6-induced cell migration. (C) 2013 Elsevier Inc. All rights reserved. | - |
dc.language | English | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.subject | METASTATIC PROSTATE-CANCER | - |
dc.subject | PROTEIN-S | - |
dc.subject | INVASION | - |
dc.subject | AXL | - |
dc.subject | PROLIFERATION | - |
dc.subject | SURVIVAL | - |
dc.subject | RECEPTOR | - |
dc.subject | LINES | - |
dc.subject | AXIS | - |
dc.title | Gas6 induces cancer cell migration and epithelial-mesenchymal transition through upregulation of MAPK and Slug | - |
dc.type | Article | - |
dc.identifier.wosid | 000318751900002 | - |
dc.identifier.scopusid | 2-s2.0-84876810119 | - |
dc.type.rims | ART | - |
dc.citation.volume | 434 | - |
dc.citation.issue | 1 | - |
dc.citation.beginningpage | 8 | - |
dc.citation.endingpage | 14 | - |
dc.citation.publicationname | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | - |
dc.identifier.doi | 10.1016/j.bbrc.2013.03.082 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.nonIdAuthor | Lee, Mira | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | METASTATIC PROSTATE-CANCER | - |
dc.subject.keywordPlus | PROTEIN-S | - |
dc.subject.keywordPlus | INVASION | - |
dc.subject.keywordPlus | AXL | - |
dc.subject.keywordPlus | PROLIFERATION | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordPlus | RECEPTOR | - |
dc.subject.keywordPlus | LINES | - |
dc.subject.keywordPlus | AXIS | - |
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