In Vivo Silicon-Based Flexible Radio Frequency Integrated Circuits Monolithically Encapsulated with Biocompatible Liquid Crystal Polymers

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Biointegrated electronics have been investigated for various healthcare applications which can introduce biomedical systems into the human body. Silicon-based semiconductors perform significant roles of nerve stimulation, signal analysis, and wireless communication in implantable electronics. However, the current large-scale integration (LSI) chips have limitations In in vivo devices due to their rigid and bulky properties. This paper describes in vivo ultrathin silicon-based liquid crystal polymer (LCP) monolithically encapsulated flexible radio frequency integrated circuits (RFICs) for medical wireless communication. The mechanical stability of the LCP encapsulation is supported by finite element analysis simulation. In vivo electrical reliability and bioaffinity of the LCP monoencapsulated RFIC devices are confirmed in rats. In vitro accelerated soak tests are performed with Arrhenius method to estimate the lifetime of LCP monoencapsulated RFICs in a live body. The work could provide an approach to flexible LSI in biointegrated electronics such as an artificial retina and wireless body sensor networks.
Publisher
AMER CHEMICAL SOC
Issue Date
2013-05
Language
English
Article Type
Article
Keywords

THIN-FILM TRANSISTORS; MICROELECTRODE ARRAYS; LARGE-AREA; ELECTRONICS; MICROSYSTEMS; TRANSPARENT; SYSTEM; CMOS

Citation

ACS NANO, v.7, no.5, pp.4545 - 4553

ISSN
1936-0851
DOI
10.1021/nn401246y
URI
http://hdl.handle.net/10203/174313
Appears in Collection
EE-Journal Papers(저널논문)MS-Journal Papers(저널논문)
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