Thermally triggered intracellular explosion of volume transition nanogels for necrotic cell death

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Here we report a novel class of super-expandable smart nanogels that undergo nano- to micro-scale volume transition in response to temperature change, applicable for thermally triggered death of cancer cells. The nanogels fabricated by light cross-linking between oligo(L-lactic acid)-poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide)-OligO(L-lactic acid) and poly(ethylene glycol) grafted poly(L-lysine) exhibited a reversible volume transition from similar to 150 nm at 37 degrees C to similar to 1.4 mu m at 15 degrees C. The abrupt and dramatic intracellular volume expansion of the nanogels upon the brief cold-shock treatment severely damaged sub-cellular self-assembled network architectures including cytoskeleton and vesicular membranes and physically ruptured cellular membrane structures, resulting in necrotic cell death. The smart "nanobomb" detonated by external stimuli could be used to effectively induce traumatic death of cells. (C) 2008 Elsevier B.V. All rights reserved
Publisher
Elsevier Science Bv
Issue Date
2009-04
Language
English
Article Type
Article
Keywords

MULTIBLOCK COPOLYMERS; CYTOSOLIC DELIVERY; DRUG-DELIVERY; NANOCAPSULES; HYDROGELS; NANOPARTICLES; DISRUPTION; APOPTOSIS; NECROSIS; CALCIUM

Citation

JOURNAL OF CONTROLLED RELEASE, v.135, no.1, pp.89 - 95

ISSN
0168-3659
DOI
10.1016/j.jconrel.2008.12.008
URI
http://hdl.handle.net/10203/174248
Appears in Collection
BS-Journal Papers(저널논문)
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