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College of Life Science and Bioengineering(생명과학기술대학)Graduate School of Medical Science & Engineering(의과학대학원)MSE-Journal Papers(저널논문)

The Frequency of CD127(+) Hepatitis C Virus (HCV)-Specific T Cells but Not the Expression of Exhaustion Markers Predicts the Outcome of Acute HCV Infection

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dc.contributor.authorShin, Eui-Cheolko
dc.contributor.authorPark, Su-Hyungko
dc.contributor.authorNascimbeni, Michelinako
dc.contributor.authorMajor, Marianko
dc.contributor.authorCaggiari, Laurako
dc.contributor.authorde Re, Valliko
dc.contributor.authorFeinstone, Stephen M.ko
dc.contributor.authorRice, Charles M.ko
dc.contributor.authorRehermann, Barbarako
dc.date.accessioned2013-06-07T07:56:36Z-
dc.date.available2013-06-07T07:56:36Z-
dc.date.created2013-05-07-
dc.date.created2013-05-07-
dc.date.issued2013-04-
dc.identifier.citationJOURNAL OF VIROLOGY, v.87, no.8, pp.4772 - 4777-
dc.identifier.issn0022-538X-
dc.identifier.urihttp://hdl.handle.net/10203/173784-
dc.description.abstractT cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T cells, but not the expression of inhibitory molecules on those T cells or their ligands in the liver, predicts the outcome of acute infection.-
dc.languageEnglish-
dc.publisherAMER SOC MICROBIOLOGY-
dc.subjectPD-1 EXPRESSION-
dc.subjectVIRAL PERSISTENCE-
dc.subjectFUNCTIONAL RESTORATION-
dc.subjectPROGRAMMED DEATH-1-
dc.subjectCD8 RESPONSES-
dc.subjectPHENOTYPE-
dc.subjectBLOCKADE-
dc.subjectLYMPHOCYTES-
dc.subjectDYSFUNCTION-
dc.subjectCHIMPANZEES-
dc.titleThe Frequency of CD127(+) Hepatitis C Virus (HCV)-Specific T Cells but Not the Expression of Exhaustion Markers Predicts the Outcome of Acute HCV Infection-
dc.typeArticle-
dc.identifier.wosid000316671000059-
dc.identifier.scopusid2-s2.0-84875785600-
dc.type.rimsART-
dc.citation.volume87-
dc.citation.issue8-
dc.citation.beginningpage4772-
dc.citation.endingpage4777-
dc.citation.publicationnameJOURNAL OF VIROLOGY-
dc.identifier.doi10.1128/JVI.03122-12-
dc.contributor.localauthorShin, Eui-Cheol-
dc.contributor.localauthorPark, Su-Hyung-
dc.contributor.nonIdAuthorNascimbeni, Michelina-
dc.contributor.nonIdAuthorMajor, Marian-
dc.contributor.nonIdAuthorCaggiari, Laura-
dc.contributor.nonIdAuthorde Re, Valli-
dc.contributor.nonIdAuthorFeinstone, Stephen M.-
dc.contributor.nonIdAuthorRice, Charles M.-
dc.contributor.nonIdAuthorRehermann, Barbara-
dc.type.journalArticleArticle-
dc.subject.keywordPlusPD-1 EXPRESSION-
dc.subject.keywordPlusVIRAL PERSISTENCE-
dc.subject.keywordPlusFUNCTIONAL RESTORATION-
dc.subject.keywordPlusPROGRAMMED DEATH-1-
dc.subject.keywordPlusCD8 RESPONSES-
dc.subject.keywordPlusPHENOTYPE-
dc.subject.keywordPlusBLOCKADE-
dc.subject.keywordPlusLYMPHOCYTES-
dc.subject.keywordPlusDYSFUNCTION-
dc.subject.keywordPlusCHIMPANZEES-
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