Small-world networks in individuals at ultra-high risk for psychosis and first-episode schizophrenia during a working memory task

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Disturbances of functional interaction between different brain regions have been hypothesized to be the major pathophysiological mechanism underlying the cognitive deficits of schizophrenia. We investigated the small-world functional networks in individuals at ultra-high risk (UHR) for psychosis, first-episode schizophrenia (FESPR) patients, and healthy controls. All participants underwent the electroencephalogram during a control task and a working memory (WM) task Small-world properties of the theta band were reduced in FESPR relative to controls during the WM task. Small-worldness of the UHR during the WM task exhibited intermediate value between that of controls and FESPR. These results imply that the suboptimal organization of the brain network may play a pivotal role in the schizophrenia pathophysiology. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
Publisher
ELSEVIER IRELAND LTD
Issue Date
2013-02
Language
English
Article Type
Article
Keywords

FUNCTIONAL CONNECTIVITY; HUMAN BRAIN; COGNITIVE DYSMETRIA; EXECUTIVE FUNCTION; SCALE-FREE; EEG; OSCILLATIONS; PERFORMANCE; DYNAMICS; SYNCHRONIZATION

Citation

NEUROSCIENCE LETTERS, v.535, pp.35 - 39

ISSN
0304-3940
DOI
10.1016/j.neulet.2012.11.051
URI
http://hdl.handle.net/10203/173485
Appears in Collection
BiS-Journal Papers(저널논문)
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