DC Field | Value | Language |
---|---|---|
dc.contributor.author | Do, Sun Hee | ko |
dc.contributor.author | Hwa, Sung-Yong | ko |
dc.contributor.author | Jeong, Won-il | ko |
dc.contributor.author | Lee, Ji-Won | ko |
dc.contributor.author | Kim, Hyun-Jung | ko |
dc.contributor.author | Lee, In-Seon | ko |
dc.contributor.author | Jeong, Kyu-Shik | ko |
dc.date.accessioned | 2010-03-11T06:33:00Z | - |
dc.date.available | 2010-03-11T06:33:00Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2007-01 | - |
dc.identifier.citation | MOLECULAR AND CELLULAR BIOCHEMISTRY, v.295, no.1-2, pp.35 - 43 | - |
dc.identifier.issn | 0300-8177 | - |
dc.identifier.uri | http://hdl.handle.net/10203/17099 | - |
dc.description.abstract | The purpose of this study was to examine the effects of ENA Actimineral Resource A (ENA-A), seaweed origin alkaline water, on postmenopausal osteoporosis in ovariectomized (OVX) rats. The 12-week old Wistar rats were divided randomly into 4 groups: ovariectomized (OVX), OVX plus 0.5% ENA-A, OVX plus 5% ENA-A and OVX plus 10% ENA-A. A histopathological analysis indicated that ENA-A could prevent OVX-induced bone loss by increasing femur trabecular bone area in a dose-dependent manner. ENA-A significantly (p < 0.05) increased serum estradiol levels, decreased serum osteocalcin activity and suppressed serum pyridinoline (PYD) levels. The in vitro effects of ENA-A were also studied using MC3T3-E1 cells. ENA-A significantly stimulated cell proliferation and increased both ALP activity and calcium deposition in a dose-dependent manner. These results suggest that the treatment of ovariectomized rats with ENA-A not only prevents bone resorption but also appears to maintain the cancellous bone structure of postmeopausal osteoporosis. | - |
dc.description.sponsorship | The work presented in this paper was supported by the Brain Korea 21 Project in 2006, Jinju Bio Food (Jinju, Korea) and the Regional Innovation Program of the Ministry of Commerce, Industry and Energy in 2006. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | SPRINGER | - |
dc.subject | BIOCHEMICAL MARKERS | - |
dc.subject | POSTMENOPAUSAL OSTEOPOROSIS | - |
dc.subject | SEX STEROIDS | - |
dc.subject | CROSS-LINKS | - |
dc.subject | TURNOVER | - |
dc.subject | ESTROGEN | - |
dc.subject | HORMONE | - |
dc.subject | WOMEN | - |
dc.subject | MASS | - |
dc.subject | METABOLISM | - |
dc.title | ENA Actimineral Resource A restores bone loss and bone quality in ovariectomized rats | - |
dc.type | Article | - |
dc.identifier.wosid | 000243659600005 | - |
dc.identifier.scopusid | 2-s2.0-33846537429 | - |
dc.type.rims | ART | - |
dc.citation.volume | 295 | - |
dc.citation.issue | 1-2 | - |
dc.citation.beginningpage | 35 | - |
dc.citation.endingpage | 43 | - |
dc.citation.publicationname | MOLECULAR AND CELLULAR BIOCHEMISTRY | - |
dc.identifier.doi | 10.1007/s11010-006-9269-5 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Jeong, Won-il | - |
dc.contributor.nonIdAuthor | Do, Sun Hee | - |
dc.contributor.nonIdAuthor | Hwa, Sung-Yong | - |
dc.contributor.nonIdAuthor | Lee, Ji-Won | - |
dc.contributor.nonIdAuthor | Kim, Hyun-Jung | - |
dc.contributor.nonIdAuthor | Lee, In-Seon | - |
dc.contributor.nonIdAuthor | Jeong, Kyu-Shik | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | bone turnover rate | - |
dc.subject.keywordAuthor | ENA Actimineral Resource A | - |
dc.subject.keywordAuthor | osteoporosis | - |
dc.subject.keywordAuthor | ovariectomy | - |
dc.subject.keywordAuthor | pyridinoline | - |
dc.subject.keywordPlus | BIOCHEMICAL MARKERS | - |
dc.subject.keywordPlus | POSTMENOPAUSAL OSTEOPOROSIS | - |
dc.subject.keywordPlus | SEX STEROIDS | - |
dc.subject.keywordPlus | CROSS-LINKS | - |
dc.subject.keywordPlus | TURNOVER | - |
dc.subject.keywordPlus | ESTROGEN | - |
dc.subject.keywordPlus | HORMONE | - |
dc.subject.keywordPlus | WOMEN | - |
dc.subject.keywordPlus | MASS | - |
dc.subject.keywordPlus | METABOLISM | - |
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