Dot1 facilitates nucleosome remodeling activities of ATP-dependent chromatin remodelers through yis nucleosome binding activity to suppress cryptic transcripts initiation in gene body region

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Dot1p (Disruptor Of Tekomeric silencing 1 in Saccharomyces cerevisiase) is a histone H3 K79 methyltransferase involved in heterochromatin boundary maintenance, DNA damage response pathway and transcriptional regulation in yeast and human. Previous ChIP analyses indicate that Dot1p is recruited in actively transcribed region. However, the exact role of Dot1 in active transcription still remain unknown.
Publisher
Cold Spring Habor Laboratory
Issue Date
2011-09-01
Language
ENG
Citation

Mechanisms of Eukaryotic transcription

URI
http://hdl.handle.net/10203/170874
Appears in Collection
BS-Conference Papers(학술회의논문)
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