DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lim, So-Hee | ko |
dc.contributor.author | Kwon, Seok-Kyu | ko |
dc.contributor.author | Lee, Myung Kyu | ko |
dc.contributor.author | Moon, Jeonghee | ko |
dc.contributor.author | Jeong, Dae Gwin | ko |
dc.contributor.author | Park, Eunha | ko |
dc.contributor.author | Kim, Seung Jun | ko |
dc.contributor.author | Park, Byung Chul | ko |
dc.contributor.author | Lee, Sang Chul | ko |
dc.contributor.author | Ryu, Seong-Eon | ko |
dc.contributor.author | Yu, Dae-Yeul | ko |
dc.contributor.author | Chung, Bong Hyun | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.contributor.author | Myung, Pyung-Keun | ko |
dc.contributor.author | Lee, Jae-Ran | ko |
dc.date.accessioned | 2010-02-02T08:35:25Z | - |
dc.date.available | 2010-02-02T08:35:25Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-11 | - |
dc.identifier.citation | EMBO JOURNAL, v.28, no.22, pp.3564 - 3578 | - |
dc.identifier.issn | 0261-4189 | - |
dc.identifier.uri | http://hdl.handle.net/10203/16425 | - |
dc.description.abstract | The receptor-type protein tyrosine phosphatases (RPTPs) have been linked to signal transduction, cell adhesion, and neurite extension. PTPRT/RPTPq is exclusively expressed in the central nervous system and regulates synapse formation by interacting with cell adhesion molecules and Fyn protein tyrosine kinase. Overexpression of PTPRT in cultured neurons increased the number of excitatory and inhibitory synapses by recruiting neuroligins that interact with PTPRT through their ecto-domains. In contrast, knockdown of PTPRT inhibited synapse formation and withered dendrites. Incubation of cultured neurons with recombinant proteins containing the extracellular region of PTPRT reduced the number of synapses by inhibiting the interaction between ecto-domains. Synapse formation by PTPRT was inhibited by phosphorylation of tyrosine 912 within the membrane-proximal catalytic domain of PTPRT by Fyn. This tyrosine phosphorylation reduced phosphatase activity of PTPRT and reinforced homophilic interactions of PTPRT, thereby preventing the heterophilic interaction between PTPRT and neuroligins. These results suggest that brain-specific PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase Fyn. The EMBO Journal (2009) 28, 3564-3578. doi:10.1038/emboj.2009.289; Published online 8 October 2009 | - |
dc.description.sponsorship | This work was supported by the Korea Science and Engineering Foundation (KOSEF), a grant funded by the Korea government (MOST) (R01-2007-000-11499-0 to J-RL), the KRIBB research initiative programme to J-RL, and the joint research collaboration programme for Chinese–Korean–Japanese research cooperation to D-YY | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | CRYSTAL-STRUCTURE | - |
dc.subject | STRUCTURAL BASIS | - |
dc.subject | PTP-MU | - |
dc.subject | EXCITATORY SYNAPSES | - |
dc.subject | NEURITE OUTGROWTH | - |
dc.subject | NERVOUS-SYSTEM | - |
dc.subject | DOMAIN 1 | - |
dc.subject | IN-VIVO | - |
dc.subject | ALPHA | - |
dc.subject | NEUROLIGINS | - |
dc.title | Synapse formation regulated by protein tyrosine phosphatase receptor T through interaction with cell adhesion molecules and Fyn | - |
dc.type | Article | - |
dc.identifier.wosid | 000271891700010 | - |
dc.identifier.scopusid | 2-s2.0-70450222110 | - |
dc.type.rims | ART | - |
dc.citation.volume | 28 | - |
dc.citation.issue | 22 | - |
dc.citation.beginningpage | 3564 | - |
dc.citation.endingpage | 3578 | - |
dc.citation.publicationname | EMBO JOURNAL | - |
dc.identifier.doi | 10.1038/emboj.2009.289 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Lim, So-Hee | - |
dc.contributor.nonIdAuthor | Lee, Myung Kyu | - |
dc.contributor.nonIdAuthor | Moon, Jeonghee | - |
dc.contributor.nonIdAuthor | Jeong, Dae Gwin | - |
dc.contributor.nonIdAuthor | Park, Eunha | - |
dc.contributor.nonIdAuthor | Kim, Seung Jun | - |
dc.contributor.nonIdAuthor | Park, Byung Chul | - |
dc.contributor.nonIdAuthor | Lee, Sang Chul | - |
dc.contributor.nonIdAuthor | Ryu, Seong-Eon | - |
dc.contributor.nonIdAuthor | Yu, Dae-Yeul | - |
dc.contributor.nonIdAuthor | Chung, Bong Hyun | - |
dc.contributor.nonIdAuthor | Myung, Pyung-Keun | - |
dc.contributor.nonIdAuthor | Lee, Jae-Ran | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | cell adhesion molecule | - |
dc.subject.keywordAuthor | Fyn | - |
dc.subject.keywordAuthor | PTPRT | - |
dc.subject.keywordAuthor | synapse formation | - |
dc.subject.keywordAuthor | tyrosine phosphorylation | - |
dc.subject.keywordPlus | CRYSTAL-STRUCTURE | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | PTP-MU | - |
dc.subject.keywordPlus | EXCITATORY SYNAPSES | - |
dc.subject.keywordPlus | NEURITE OUTGROWTH | - |
dc.subject.keywordPlus | NERVOUS-SYSTEM | - |
dc.subject.keywordPlus | DOMAIN 1 | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | ALPHA | - |
dc.subject.keywordPlus | NEUROLIGINS | - |
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