Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD

Cited 41 time in webofscience Cited 0 time in scopus
  • Hit : 229
  • Download : 399
DC FieldValueLanguage
dc.contributor.authorHan, Kihoonko
dc.contributor.authorKim, Myoung-Hwanko
dc.contributor.authorSeeburg, Danielko
dc.contributor.authorSeo, Jinsooko
dc.contributor.authorVerpelli, Chiarako
dc.contributor.authorHan, Seungnamko
dc.contributor.authorChung, Hye Sunko
dc.contributor.authorKo, Jaewonko
dc.contributor.authorLee, Hyun Wooko
dc.contributor.authorKim, Karamko
dc.contributor.authorHeo, Won Doko
dc.contributor.authorMeyer, Tobiasko
dc.contributor.authorKim, Hyunko
dc.contributor.authorSala, Carloko
dc.contributor.authorChoi, Se-Youngko
dc.contributor.authorSheng, Morganko
dc.contributor.authorKim, Eunjoonko
dc.date.accessioned2010-02-02T08:20:50Z-
dc.date.available2010-02-02T08:20:50Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2009-09-
dc.identifier.citationPLOS BIOLOGY, v.7, no.9-
dc.identifier.issn1544-9173-
dc.identifier.urihttp://hdl.handle.net/10203/16424-
dc.description.abstractLong-term depression (LTD) is a long-lasting activity-dependent decrease in synaptic strength. NMDA receptor ( NMDAR) dependent LTD, an extensively studied form of LTD, involves the endocytosis of AMPA receptors (AMPARs) via protein dephosphorylation, but the underlying mechanism has remained unclear. We show here that a regulated interaction of the endocytic adaptor RalBP1 with two synaptic proteins, the small GTPase RalA and the postsynaptic scaffolding protein PSD-95, controls NMDAR-dependent AMPAR endocytosis during LTD. NMDAR activation stimulates RalA, which binds and translocates widespread RalBP1 to synapses. In addition, NMDAR activation dephosphorylates RalBP1, promoting the interaction of RalBP1 with PSD-95. These two regulated interactions are required for NMDAR-dependent AMPAR endocytosis and LTD and are sufficient to induce AMPAR endocytosis in the absence of NMDAR activation. RalA in the basal state, however, maintains surface AMPARs. We propose that NMDAR activation brings RalBP1 close to PSD-95 to promote the interaction of RalBP1-associated endocytic proteins with PSD-95-associated AMPARs. This suggests that scaffolding proteins at specialized cellular junctions can switch their function from maintenance to endocytosis of interacting membrane proteins in a regulated manner.-
dc.description.sponsorshipThis work was supported by the Creative Research Initiatives Program of the Korean Ministry of Science and Technology (to EK); the Korea Science and Engineering Foundation M10500000049-05J0000-04900 (to HK); Telethon-Italy GGP06208, Fondazione Cariplo 2006-0779, and Compagnia di San Paolo 2005-1964 (to CS); and a National Institute of Health grant R01MH064801 (to TM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherPUBLIC LIBRARY SCIENCE-
dc.subjectLONG-TERM DEPRESSION-
dc.subjectSYNAPTIC PLASTICITY-
dc.subjectPOSTSYNAPTIC DENSITY-
dc.subjectGLUTAMATE RECEPTORS-
dc.subjectEXCITATORY SYNAPSES-
dc.subjectAUXILIARY SUBUNITS-
dc.subjectPROTEOMIC ANALYSIS-
dc.subjectHIPPOCAMPAL LTD-
dc.subjectNMDA RECEPTORS-
dc.subjectGLUR1 SUBUNIT-
dc.titleRegulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD-
dc.typeArticle-
dc.identifier.alternativecitationhttp://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000187en
dc.identifier.wosid000270820800002-
dc.identifier.scopusid2-s2.0-70349780603-
dc.type.rimsART-
dc.citation.volume7-
dc.citation.issue9-
dc.citation.publicationnamePLOS BIOLOGY-
dc.identifier.doi10.1371/journal.pbio.1000187-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorHeo, Won Do-
dc.contributor.localauthorKim, Eunjoon-
dc.contributor.nonIdAuthorHan, Kihoon-
dc.contributor.nonIdAuthorKim, Myoung-Hwan-
dc.contributor.nonIdAuthorSeeburg, Daniel-
dc.contributor.nonIdAuthorSeo, Jinsoo-
dc.contributor.nonIdAuthorVerpelli, Chiara-
dc.contributor.nonIdAuthorHan, Seungnam-
dc.contributor.nonIdAuthorChung, Hye Sun-
dc.contributor.nonIdAuthorKo, Jaewon-
dc.contributor.nonIdAuthorLee, Hyun Woo-
dc.contributor.nonIdAuthorKim, Karam-
dc.contributor.nonIdAuthorMeyer, Tobias-
dc.contributor.nonIdAuthorKim, Hyun-
dc.contributor.nonIdAuthorSala, Carlo-
dc.contributor.nonIdAuthorChoi, Se-Young-
dc.contributor.nonIdAuthorSheng, Morgan-
dc.type.journalArticleArticle-
dc.subject.keywordPlusLONG-TERM DEPRESSION-
dc.subject.keywordPlusSYNAPTIC PLASTICITY-
dc.subject.keywordPlusPOSTSYNAPTIC DENSITY-
dc.subject.keywordPlusGLUTAMATE RECEPTORS-
dc.subject.keywordPlusEXCITATORY SYNAPSES-
dc.subject.keywordPlusAUXILIARY SUBUNITS-
dc.subject.keywordPlusPROTEOMIC ANALYSIS-
dc.subject.keywordPlusHIPPOCAMPAL LTD-
dc.subject.keywordPlusNMDA RECEPTORS-
dc.subject.keywordPlusGLUR1 SUBUNIT-
Appears in Collection
BS-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 41 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0