DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Kihoon | ko |
dc.contributor.author | Kim, Myoung-Hwan | ko |
dc.contributor.author | Seeburg, Daniel | ko |
dc.contributor.author | Seo, Jinsoo | ko |
dc.contributor.author | Verpelli, Chiara | ko |
dc.contributor.author | Han, Seungnam | ko |
dc.contributor.author | Chung, Hye Sun | ko |
dc.contributor.author | Ko, Jaewon | ko |
dc.contributor.author | Lee, Hyun Woo | ko |
dc.contributor.author | Kim, Karam | ko |
dc.contributor.author | Heo, Won Do | ko |
dc.contributor.author | Meyer, Tobias | ko |
dc.contributor.author | Kim, Hyun | ko |
dc.contributor.author | Sala, Carlo | ko |
dc.contributor.author | Choi, Se-Young | ko |
dc.contributor.author | Sheng, Morgan | ko |
dc.contributor.author | Kim, Eunjoon | ko |
dc.date.accessioned | 2010-02-02T08:20:50Z | - |
dc.date.available | 2010-02-02T08:20:50Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-09 | - |
dc.identifier.citation | PLOS BIOLOGY, v.7, no.9 | - |
dc.identifier.issn | 1544-9173 | - |
dc.identifier.uri | http://hdl.handle.net/10203/16424 | - |
dc.description.abstract | Long-term depression (LTD) is a long-lasting activity-dependent decrease in synaptic strength. NMDA receptor ( NMDAR) dependent LTD, an extensively studied form of LTD, involves the endocytosis of AMPA receptors (AMPARs) via protein dephosphorylation, but the underlying mechanism has remained unclear. We show here that a regulated interaction of the endocytic adaptor RalBP1 with two synaptic proteins, the small GTPase RalA and the postsynaptic scaffolding protein PSD-95, controls NMDAR-dependent AMPAR endocytosis during LTD. NMDAR activation stimulates RalA, which binds and translocates widespread RalBP1 to synapses. In addition, NMDAR activation dephosphorylates RalBP1, promoting the interaction of RalBP1 with PSD-95. These two regulated interactions are required for NMDAR-dependent AMPAR endocytosis and LTD and are sufficient to induce AMPAR endocytosis in the absence of NMDAR activation. RalA in the basal state, however, maintains surface AMPARs. We propose that NMDAR activation brings RalBP1 close to PSD-95 to promote the interaction of RalBP1-associated endocytic proteins with PSD-95-associated AMPARs. This suggests that scaffolding proteins at specialized cellular junctions can switch their function from maintenance to endocytosis of interacting membrane proteins in a regulated manner. | - |
dc.description.sponsorship | This work was supported by the Creative Research Initiatives Program of the Korean Ministry of Science and Technology (to EK); the Korea Science and Engineering Foundation M10500000049-05J0000-04900 (to HK); Telethon-Italy GGP06208, Fondazione Cariplo 2006-0779, and Compagnia di San Paolo 2005-1964 (to CS); and a National Institute of Health grant R01MH064801 (to TM). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.title | Regulated RalBP1 Binding to RalA and PSD-95 Controls AMPA Receptor Endocytosis and LTD | - |
dc.type | Article | - |
dc.identifier.alternativecitation | http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1000187 | en |
dc.identifier.wosid | 000270820800002 | - |
dc.identifier.scopusid | 2-s2.0-70349780603 | - |
dc.type.rims | ART | - |
dc.citation.volume | 7 | - |
dc.citation.issue | 9 | - |
dc.citation.publicationname | PLOS BIOLOGY | - |
dc.identifier.doi | 10.1371/journal.pbio.1000187 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Heo, Won Do | - |
dc.contributor.localauthor | Kim, Eunjoon | - |
dc.contributor.nonIdAuthor | Han, Kihoon | - |
dc.contributor.nonIdAuthor | Kim, Myoung-Hwan | - |
dc.contributor.nonIdAuthor | Seeburg, Daniel | - |
dc.contributor.nonIdAuthor | Seo, Jinsoo | - |
dc.contributor.nonIdAuthor | Verpelli, Chiara | - |
dc.contributor.nonIdAuthor | Han, Seungnam | - |
dc.contributor.nonIdAuthor | Chung, Hye Sun | - |
dc.contributor.nonIdAuthor | Ko, Jaewon | - |
dc.contributor.nonIdAuthor | Lee, Hyun Woo | - |
dc.contributor.nonIdAuthor | Kim, Karam | - |
dc.contributor.nonIdAuthor | Meyer, Tobias | - |
dc.contributor.nonIdAuthor | Kim, Hyun | - |
dc.contributor.nonIdAuthor | Sala, Carlo | - |
dc.contributor.nonIdAuthor | Choi, Se-Young | - |
dc.contributor.nonIdAuthor | Sheng, Morgan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | LONG-TERM DEPRESSION | - |
dc.subject.keywordPlus | SYNAPTIC PLASTICITY | - |
dc.subject.keywordPlus | POSTSYNAPTIC DENSITY | - |
dc.subject.keywordPlus | GLUTAMATE RECEPTORS | - |
dc.subject.keywordPlus | EXCITATORY SYNAPSES | - |
dc.subject.keywordPlus | AUXILIARY SUBUNITS | - |
dc.subject.keywordPlus | PROTEOMIC ANALYSIS | - |
dc.subject.keywordPlus | HIPPOCAMPAL LTD | - |
dc.subject.keywordPlus | NMDA RECEPTORS | - |
dc.subject.keywordPlus | GLUR1 SUBUNIT | - |
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