표면의 구조적 특성이 세포 부착 양상에 미치는 영향Effects of surface geometrical properties on cellular adhesion behavior

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An understanding of cell–substrate interactions can provide insight into the complex interactions between the cell and its natural environment. Geometrical surface properties can influence the cell adhesion behavior, which is a fundamental process directly involved in cell growth, cell migration and cell differentiation. In this study, the phenomenon of cells displaying preference toward surface with irregular roughness generated by polystyrene islands (0.2m in diameter) has been investigated. Fibroblasts on surfaces of different roughness exhibited clear preference toward the rougher region, with larger cell spreading area and the degree of stretching. This preference was maintained even when the extracellular matrix (ECM) proteins were eliminated from the surface. Cells on the surfaces with irregular ECM protein coating did not display any preference, and showed insignificant differences in morphology. Our results reveal that geometrical surface properties can regulate cell adhesion behavior, which can lead to extensive understanding of how cells recognize surface features and react to them.
Publisher
대한기계학회
Issue Date
2009-11-06
Language
KOR
Citation

대한기계학회 2009년도 추계학술대회, pp.2963 - 2966

URI
http://hdl.handle.net/10203/163356
Appears in Collection
ME-Conference Papers(학술회의논문)
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