Metabolic control analysis of various dynamic behaviors of biochemical systems

Abstract

Metabolic control analysis is a useful tool to understand and predict the dynamic behaviors of biochemical systems. While the classical metabolic control coefficients are defined only for the systems with steady-state trajectories, many important dynamic behaviors do not reach the steady-state, but show the oscillatory or irregular behaviors. This study proposes the investigation scheme for metabolic control analysis of the every dynamic system regardless of the existence of steady-state, by classifying the systems into three groups: the systems with steady-state trajectories, autonomously oscillating systems and the other systems with irregular behaviors.