A scheme of shape optimization by new approximation approach is applied to design of a flow guide in three-dimensional extrusion processes. The optimization scheme is presented to reduce computation time fur the optimization process and applied to an H-section extrusion problem for verifying the efficiency and the usefulness. The object of optimization is to minimize the deviation of exit velocity and control points of a Bezier curve describing the shape of the flow guide are regarded as design variables. The effectiveness of the proposed scheme is then demonstrated through the applied example.