Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | La, Muhnho | - |
| dc.contributor.author | Kim, Karam | - |
| dc.contributor.author | Park, Jinhwi | - |
| dc.contributor.author | Won, Jungyeon | - |
| dc.contributor.author | Lee, Jeung-Hoon | - |
| dc.contributor.author | Fu, Ya-Min | - |
| dc.contributor.author | Meadows, Gary G. | - |
| dc.contributor.author | Joe, Cheol O. | - |
| dc.date.accessioned | 2009-12-08T02:36:29Z | - |
| dc.date.available | 2009-12-08T02:36:29Z | - |
| dc.date.issued | 2004-07-30 | - |
| dc.identifier.citation | Biochemical and Biophysical Research Communications, Vol.320, No.3, pp.760-765 | en |
| dc.identifier.issn | 0006-291X | - |
| dc.identifier.uri | http://hdl.handle.net/10203/14362 | - |
| dc.description.abstract | Daxx-mediated transcriptional repression was modulated by a speckled POZ domain protein SPOP which was first identified as an autoantigen from the serum of a scleroderma patient. This is the first report on the biochemical and functional interactions between Daxx and SPOP. The COOH-terminal region of Daxx interacts with the NH2-terminal region of SPOP. SPOP reversed the transcriptional repression mediated by Daxx which binds with ETS1 transcription factor to repress ETS1-responsive gene expression. Mutagenesis study suggests that the ability of SPOP to self-associate as well as its ability to bind with Daxx was important for the modulation of Daxx-mediated transcriptional repression. | en |
| dc.description.sponsorship | We are grateful to Dr. R. Li (Medical University of South Carolina, USA) for providing cDNA of ETS1, Dr. E. Evance (Salk Institute, USA) for providing cDNA of PMLIV, Dr. E. Brinckerhoff (Dartmouth Medical School, USA) for providing MMP1 promoter construct coupled with luciferase reporter gene, and Dr. M. Hagiwara (Tokyo Medical and Dental University, Japan) for providing cDNA of SPOP. This work was supported in part by a grant from Molecular Medicine Research Group Program, Ministry of Science and Technology, Korea, a grant from Korean National Cancer Control Program, Ministry of Health and Welfare, and a grant from Brain Korea 21 Project, Korea Research Foundation. | en |
| dc.language.iso | en_US | en |
| dc.publisher | Elsevier | en |
| dc.subject | Daxx | en |
| dc.subject | ETS1 | en |
| dc.subject | MMP1 | en |
| dc.subject | Scleroderma | en |
| dc.subject | SPOP | en |
| dc.title | Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP | en |
| dc.type | Article | en |
| dc.identifier.doi | 10.1016/j.bbrc.2004.06.022 | - |
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