Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP

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Daxx-mediated transcriptional repression was modulated by a speckled POZ domain protein SPOP which was first identified as an autoantigen from the serum of a scleroderma patient. This is the first report on the biochemical and functional interactions between Daxx and SPOP. The COOH-terminal region of Daxx interacts with the NH2-terminal region of SPOP. SPOP reversed the transcriptional repression mediated by Daxx which binds with ETS1 transcription factor to repress ETS1-responsive gene expression. Mutagenesis study suggests that the ability of SPOP to self-associate as well as its ability to bind with Daxx was important for the modulation of Daxx-mediated transcriptional repression.
Publisher
Elsevier
Issue Date
2004-07-30
Keywords

Daxx; ETS1; MMP1; Scleroderma; SPOP

Citation

Biochemical and Biophysical Research Communications, Vol.320, No.3, pp.760-765

ISSN
0006-291X
DOI
10.1016/j.bbrc.2004.06.022
URI
http://hdl.handle.net/10203/14362
Appears in Collection
BS-Conference Papers(학술회의논문)

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