DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Eui-Cheol | ko |
dc.contributor.author | Capone, Stefania | ko |
dc.contributor.author | Cortese, Riccardo | ko |
dc.contributor.author | Colloca, Stefano | ko |
dc.contributor.author | Nicosia, Alfredo | ko |
dc.contributor.author | Folgori, Antonella | ko |
dc.contributor.author | Rehermann, Barbara | ko |
dc.date.accessioned | 2009-11-30T08:44:29Z | - |
dc.date.available | 2009-11-30T08:44:29Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2008-10 | - |
dc.identifier.citation | JOURNAL OF VIROLOGY, v.82, no.19, pp.9782 - 9788 | - |
dc.identifier.issn | 0022-538X | - |
dc.identifier.uri | http://hdl.handle.net/10203/13711 | - |
dc.description.abstract | Peripheral blood T-cell responses are used as biomarkers in hepatitis C virus (HCV) vaccine trials. However, it is not clear how T-cell responses in the blood correlate with those in the liver, the infection site. By studying serial liver and blood samples of five vaccinated and five mock-vaccinated control chimpanzees during acute HCV infection, we demonstrate a correlation between HCV-specific CD8 T-cell responses in the blood and molecular and functional markers of T-cell responses in the liver. Thus, HCV-specific CD8 T-cell responses in the blood are valid markers for intrahepatic T-cell activity. | - |
dc.description.sponsorship | This work was supported in part by the NIDDK, NIH intramural research program. | en |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | AMER SOC MICROBIOLOGY | - |
dc.subject | IMMUNE-RESPONSES | - |
dc.subject | VIRAL CLEARANCE | - |
dc.subject | PERSISTENCE | - |
dc.subject | CHIMPANZEES | - |
dc.subject | DETERMINANTS | - |
dc.subject | RECOVERY | - |
dc.title | The kinetics of hepatitis C virus-specific CD8 T-cell responses in the blood mirror those in the liver in acute hepatitis C virus infection | - |
dc.type | Article | - |
dc.identifier.wosid | 000259259700046 | - |
dc.identifier.scopusid | 2-s2.0-52649108694 | - |
dc.type.rims | ART | - |
dc.citation.volume | 82 | - |
dc.citation.issue | 19 | - |
dc.citation.beginningpage | 9782 | - |
dc.citation.endingpage | 9788 | - |
dc.citation.publicationname | JOURNAL OF VIROLOGY | - |
dc.identifier.doi | 10.1128/JVI.00475-08 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Shin, Eui-Cheol | - |
dc.contributor.nonIdAuthor | Capone, Stefania | - |
dc.contributor.nonIdAuthor | Cortese, Riccardo | - |
dc.contributor.nonIdAuthor | Colloca, Stefano | - |
dc.contributor.nonIdAuthor | Nicosia, Alfredo | - |
dc.contributor.nonIdAuthor | Folgori, Antonella | - |
dc.contributor.nonIdAuthor | Rehermann, Barbara | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordPlus | IMMUNE-RESPONSES | - |
dc.subject.keywordPlus | VIRAL CLEARANCE | - |
dc.subject.keywordPlus | PERSISTENCE | - |
dc.subject.keywordPlus | CHIMPANZEES | - |
dc.subject.keywordPlus | DETERMINANTS | - |
dc.subject.keywordPlus | RECOVERY | - |
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