DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Hyukjin | ko |
dc.contributor.author | Park, Tae Gwan | ko |
dc.date.accessioned | 2009-11-25T04:40:03Z | - |
dc.date.available | 2009-11-25T04:40:03Z | - |
dc.date.created | 2012-02-06 | - |
dc.date.created | 2012-02-06 | - |
dc.date.issued | 2009-03 | - |
dc.identifier.citation | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, v.88A, no.3, pp.797 - 806 | - |
dc.identifier.issn | 1549-3296 | - |
dc.identifier.uri | http://hdl.handle.net/10203/13317 | - |
dc.description.abstract | Hyaluronic acid (HA) grafted with Pluronic F127 copolymer was used as biomimetic hydrogels for cell delivery. The graft copolymer was synthesized by conjugating amine end-capped Pluronic F127 to carboxylic groups of HA using coupling agents. The synthesized HA-g-Pluronic exhibited thermo-sensitive sol-gel transition behaviors over the temperature range of 20-40 degrees C. HA-g-Pluronic copolymers with vinyl groups were photo-crosslinked to prepare more robust hydrogels for cell cultivation. For improved cellular adhesion and proliferation, cell adhesive peptide (Arg-Gly-Asp (RGD)) was additionally conjugated to the HA backbone. The resultant thermo-sensitive, photocrosslinkable, and RGD modified HA-g-Pluronic copolymers were used to encapsulate and cultivate bovine chondrocytes in vitro. A tissue containing cartilage-like components such as GAG and type II collagen was successfully produced within the hydrogels, indicating that the synthesized HA-g-Pluronic copolymers can be potentially used as an injectable cell carrier. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 88A: 797-806,2009 | - |
dc.language | English | - |
dc.language.iso | en_US | en |
dc.publisher | Wiley-Blackwell | - |
dc.subject | IN-SITU GELATION | - |
dc.subject | CONTROLLED-RELEASE | - |
dc.subject | HYDROGELS | - |
dc.subject | POLYANHYDRIDES | - |
dc.subject | DERIVATIVES | - |
dc.subject | SYSTEMS | - |
dc.subject | TISSUE | - |
dc.title | Photo-crosslinkable, biomimetic, and thermo-sensitive pluronic grafted hyaluronic acid copolymers for injectable delivery of chondrocytes | - |
dc.type | Article | - |
dc.identifier.wosid | 000263126000028 | - |
dc.identifier.scopusid | 2-s2.0-60549086138 | - |
dc.type.rims | ART | - |
dc.citation.volume | 88A | - |
dc.citation.issue | 3 | - |
dc.citation.beginningpage | 797 | - |
dc.citation.endingpage | 806 | - |
dc.citation.publicationname | JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A | - |
dc.identifier.doi | 10.1002/jbm.a.31983 | - |
dc.embargo.liftdate | 9999-12-31 | - |
dc.embargo.terms | 9999-12-31 | - |
dc.contributor.localauthor | Park, Tae Gwan | - |
dc.type.journalArticle | Article | - |
dc.subject.keywordAuthor | injectable | - |
dc.subject.keywordAuthor | pluronic | - |
dc.subject.keywordAuthor | hyaluronic acid | - |
dc.subject.keywordAuthor | temperature-sensitive | - |
dc.subject.keywordAuthor | chondrocytes | - |
dc.subject.keywordPlus | IN-SITU GELATION | - |
dc.subject.keywordPlus | CONTROLLED-RELEASE | - |
dc.subject.keywordPlus | HYDROGELS | - |
dc.subject.keywordPlus | POLYANHYDRIDES | - |
dc.subject.keywordPlus | DERIVATIVES | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.subject.keywordPlus | TISSUE | - |
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