Biodegradable PLGA microcarriers for injectable delivery of chondrocytes: Effect of surface modification on cell attachment and function

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Poly(D,L-lactic-co-glycolic acid) (PLGA) microspheres were prepared by an oil/water emulsion solvent evaporation method to use as an injectable microcarrier for cell delivery. Three different kinds of PLGA microspheres having hydrophobic, negatively charged, and positively charged surfaces were prepared. Hydrophobic and negatively charged PLGA microspheres were prepared by using terminally capped and uncapped PLGA polymer, respectively. Positively charged PLGA microspheres were prepared by blending PLGA with PLGA-g-poly(L-lysine) graft copolymer as a surface modifying agent. Bovine chondrocytes were cultured on the three PLGA microspheres under serum conditions to comparatively evaluate cell attachment, cell proliferation, and cell function with respect to surface properties. Positively charged PLGA microspheres showed the highest cell attachment, growth, and function compared to hydrophobic and negatively charged microspheres. Surface-modified PLGA microspheres can potentially be used as an injectable delivery system for cells into a tissue defect site.
Publisher
AMER CHEMICAL SOC
Issue Date
2004
Language
English
Article Type
Article
Keywords

POLYMER SCAFFOLDS; CARTILAGE DEFECTS; RGD-PEPTIDE; GROWTH; MATRIX; MICROPARTICLES; BIOMATERIAL; EXPRESSION; CULTURE; FILMS

Citation

BIOTECHNOLOGY PROGRESS, v.20, no.6, pp.1797 - 1801

ISSN
8756-7938
DOI
10.1021/bp0496981
URI
http://hdl.handle.net/10203/13299
Appears in Collection
BS-Journal Papers(저널논문)
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