Folate receptor targeted delivery of polyelectrolyte complex micelles prepared from ODN-PEG-Folate conjugate and cationic lipids

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dc.contributor.authorKim, Sun-Hwako
dc.contributor.authorJeong, Ji-Hoonko
dc.contributor.authorMok, Hye-Jungko
dc.contributor.authorLee, Soo-Hyeonko
dc.contributor.authorKim, Sung-Wanko
dc.contributor.authorPark, Tae-Gwanko
dc.date.accessioned2009-11-24T06:48:30Z-
dc.date.available2009-11-24T06:48:30Z-
dc.date.created2012-02-06-
dc.date.created2012-02-06-
dc.date.issued2007-
dc.identifier.citationBIOTECHNOLOGY PROGRESS, v.23, no.1, pp.232 - 237-
dc.identifier.issn8756-7938-
dc.identifier.urihttp://hdl.handle.net/10203/13223-
dc.description.abstractA polyelectrolyte complex micelle (PECM)-based delivery system for targeting folate (FOL) receptor overexpressing tumor cells is demonstrated using poly(ethylene glycol) (PEG)-conjugated oligonucleotide (ODN). The tumor targeting property was conferred to the PECM by tethering a folate moiety to the distal end of the PEG segment in an anti-sense green fluorescent protein (GFP) ODN-PEG conjugate. Nanoscale PECMs were spontaneously produced from ionic interactions between the ODN-PEG-FOL conjugate and a cationic lipid, lipofectamine (Lf). When treated with FOL receptor overexpressing cells (KB), the PCEMs caused a significant reduction in GFP expression in a dose-dependent manner. This effect was not observed in FOL receptor deficient cells (A549). The enhanced transfection of ODN-PEG-FOL/Lf PECMs to KB cells was caused by FOL receptor mediated endocytosis. The efficiency of target-specific gene suppression by ODN-PEG-FOL/Lf PECMs was maintained even in the presence of 10% fetal bovine serum in the transfection medium.-
dc.description.sponsorshipNational Research Laboratory Grant from the Ministry of Science and Technology, Republic of Korea.en
dc.languageEnglish-
dc.language.isoen_USen
dc.publisherWiley-Blackwell-
dc.subjectBLOCK-COPOLYMER MICELLES-
dc.subjectGENE DELIVERY-
dc.subjectANTISENSE OLIGONUCLEOTIDES-
dc.subjectINTRACELLULAR DELIVERY-
dc.subjectGLYCOL) CONJUGATE-
dc.subjectCELLULAR UPTAKE-
dc.subjectDRUG-
dc.subjectDNA-
dc.subjectPOLY(ETHYLENIMINE)-
dc.subjectSTABILIZATION-
dc.titleFolate receptor targeted delivery of polyelectrolyte complex micelles prepared from ODN-PEG-Folate conjugate and cationic lipids-
dc.typeArticle-
dc.identifier.wosid000243927600032-
dc.identifier.scopusid2-s2.0-33847168570-
dc.type.rimsART-
dc.citation.volume23-
dc.citation.issue1-
dc.citation.beginningpage232-
dc.citation.endingpage237-
dc.citation.publicationnameBIOTECHNOLOGY PROGRESS-
dc.embargo.liftdate9999-12-31-
dc.embargo.terms9999-12-31-
dc.contributor.localauthorPark, Tae-Gwan-
dc.contributor.nonIdAuthorKim, Sun-Hwa-
dc.contributor.nonIdAuthorJeong, Ji-Hoon-
dc.contributor.nonIdAuthorMok, Hye-Jung-
dc.contributor.nonIdAuthorKim, Sung-Wan-
dc.type.journalArticleArticle-
dc.subject.keywordPlusBLOCK-COPOLYMER MICELLES-
dc.subject.keywordPlusGENE DELIVERY-
dc.subject.keywordPlusANTISENSE OLIGONUCLEOTIDES-
dc.subject.keywordPlusINTRACELLULAR DELIVERY-
dc.subject.keywordPlusGLYCOL) CONJUGATE-
dc.subject.keywordPlusCELLULAR UPTAKE-
dc.subject.keywordPlusDRUG-
dc.subject.keywordPlusDNA-
dc.subject.keywordPlusPOLY(ETHYLENIMINE)-
dc.subject.keywordPlusSTABILIZATION-
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