Heparin-immobilized biodegradable scaffolds for local and sustained release of angiogenic growth factor

Cited 101 time in webofscience Cited 0 time in scopus
  • Hit : 454
  • Download : 308
Heparin-immobilized porous biodegradable scaffolds were fabricated to release basic fibroblast growth factor (bFGF) in a sustained manner. Heparin was covalently conjugated onto the surface of macroporous PLGA scaffolds fabricated by a gas-foaming/salt-leaching method. Sustained release of bFGF was successfully achieved for over 20 days due to high affinity of bFGF onto the immobilized heparin. It appears that bFGF release rate was regulated by the specific interaction between bFGF and heparin. The bFGF fraction released from the scaffolds maintained its bioactivity, as judged from determining the proliferation extent of human umbilical vein endothelial cells (HUVECs) in vitro. When heparin-immobilized scaffolds loaded with bFGF were implanted subcutaneously in vivo, they effectively induced the formation of blood vessels in the vicinity of the implant site. This study demonstrated that local and sustained delivery of angiogenic growth factor for tissue regeneration could be achieved by surface modification of porous scaffolds with heparin. (c) 2006 Wiley Periodicals, Inc.
Publisher
WILEY-LISS
Issue Date
2006-12
Language
English
Article Type
Article
Keywords

FOAMING/SALT-LEACHING METHOD; POLYMER SCAFFOLDS; EFFERVESCENT SALTS; DELIVERY; BINDING; SURFACE; HEPATOCYTES; GALACTOSE; CARTILAGE; MATRICES

Citation

JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A, v.79A, no.4, pp.934 - 942

ISSN
1549-3296
DOI
10.1002/jbm.a.30843
URI
http://hdl.handle.net/10203/13220
Appears in Collection
NT-Journal Papers(저널논문)BS-Journal Papers(저널논문)
Files in This Item
This item is cited by other documents in WoS
⊙ Detail Information in WoSⓡ Click to see webofscience_button
⊙ Cited 101 items in WoS Click to see citing articles in records_button

qr_code

  • mendeley

    citeulike


rss_1.0 rss_2.0 atom_1.0